| Chapter title |
IL-11Rα: A Novel Target for the Treatment of Osteosarcoma.
|
|---|---|
| Chapter number | 15 |
| Book title |
Current Advances in Osteosarcoma
|
| Published in |
Advances in experimental medicine and biology, May 2014
|
| DOI | 10.1007/978-3-319-04843-7_15 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-904842-0, 978-3-31-904843-7
|
| Authors |
Lewis VO, Lewis, Valerae O., Valerae O. Lewis |
| Abstract |
Recent advances have shown that cell surface receptors are expressed differentially in normal and pathological conditions. Novel organ specific and disease specific proteins expressed on tumor vasculature have been identified by in vivo phage display technology and the diversity of the tumor-associated vasculature has provided the basis for the development of targeted therapeutics. Investigators recently screened a phage display library in a human cancer patient. An IL-11 mimic phage displaying the cyclic peptide CGRRAGGSC (single letter amino acid code) specifically bound to immobilized IL-11Rα. It has been demonstrated that the expression of the IL-11Rα is increased in several other types of tumors including osteosarcoma. The ability to selectively target the IL-11Rα may provide an alternative treatment of for a disease where new treatment options are truly needed. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 9 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 22% |
| Professor | 1 | 11% |
| Student > Postgraduate | 1 | 11% |
| Student > Doctoral Student | 1 | 11% |
| Unknown | 4 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 1 | 11% |
| Agricultural and Biological Sciences | 1 | 11% |
| Medicine and Dentistry | 1 | 11% |
| Design | 1 | 11% |
| Unknown | 5 | 56% |