Chapter title |
Natural Killer Cells for Osteosarcoma.
|
---|---|
Chapter number | 19 |
Book title |
Current Advances in Osteosarcoma
|
Published in |
Advances in experimental medicine and biology, May 2014
|
DOI | 10.1007/978-3-319-04843-7_19 |
Pubmed ID | |
Book ISBNs |
978-3-31-904842-0, 978-3-31-904843-7
|
Authors |
Nidale Tarek, Dean A Lee, Tarek, Nidale, Lee, Dean A., Dean A. Lee |
Abstract |
Natural killer (NK) cells are lymphocytes of the innate immune system that have the ability to recognize malignant cells through detection of a variety of cell-surface indicators of stress and danger. Once activated through such recognition, NK cells release cytokines and induce target cell lysis through a variety of mechanisms. NK cells are increasingly recognized as important mediators of other immunotherapeutic modalities, including cytokines, antibodies, immunomodulators, and stem cell transplantation. Adoptive immunotherapies with NK cells are being tested in early-stage clinical trials, and recent advances in manipulating their number and function have caused a renewed emphasis on this cancer-fighting cell. In this chapter we address the evidence for NK cell recognition of osteosarcoma in vitro and in vivo, discuss new therapies that are directly or indirectly dependent on NK cell function, and describe potential approaches for manipulating NK cell number and function to enhance therapy against osteosarcoma. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 4% |
Unknown | 25 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 12% |
Student > Doctoral Student | 3 | 12% |
Student > Bachelor | 3 | 12% |
Other | 2 | 8% |
Professor | 2 | 8% |
Other | 9 | 35% |
Unknown | 4 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 31% |
Biochemistry, Genetics and Molecular Biology | 6 | 23% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
Immunology and Microbiology | 2 | 8% |
Agricultural and Biological Sciences | 1 | 4% |
Other | 1 | 4% |
Unknown | 6 | 23% |