Chapter title |
Analysis of Chromosomal Alterations in Urothelial Carcinoma
|
---|---|
Chapter number | 1 |
Book title |
Urothelial Carcinoma
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7234-0_1 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7233-3, 978-1-4939-7234-0
|
Authors |
Donatella Conconi, Angela Bentivegna, Conconi, Donatella, Bentivegna, Angela |
Abstract |
Here, we describe the use of complementary techniques applicable to different types of samples to analyze chromosomal alterations in urothelial carcinoma. By a conventional chromosome analysis on fresh biopsies, it is possible to delineate the status of ploidy and rough chromosomal aberrations. The multi-target fluorescence in situ hybridization (FISH) UroVysion test, for the rapid detection of chromosomal aneusomy of chromosomes 3, 7, and 17 and/or deletion of 9p21 locus, is applicable to urine specimens as well as to formalin-fixed paraffin-embedded (FFPE) specimens and fresh biopsies. Finally, array comparative genomic hybridization (array-CGH) gives the possibility of analyzing the DNA in a single experiment from a biopsy of the tumor but also from FFPE specimens; this technique is able to detect alterations at the genome level not excluding any chromosome. |
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