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Protein Expression in Down Syndrome Brain

Overview of attention for book
Cover of 'Protein Expression in Down Syndrome Brain'

Table of Contents

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    Book Overview
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    Chapter 1 Decreased alpha-endosulfine, an endogenous regulator of ATP-sensitive potassium channels, in brains from adult Down syndrome patients
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    Chapter 2 Developmental instability of the cerebellum and its relevance to Down syndrome
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    Chapter 3 Expression of the multidrug resistance P glycoprotein (Pgp) and multidrug resistance associated protein (MRP1) in Down syndrome brains
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    Chapter 4 Deterioration of the transcriptional, splicing and elongation machinery in brain of fetal Down Syndrome
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    Chapter 5 Fetal life in Down syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure.
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    Chapter 6 Antioxidant proteins in fetal brain: superoxide dismutase-1 (SOD-1) protein is not overexpressed in fetal Down syndrome
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    Chapter 7 Glial-neurotrophic mechanisms in Down syndrome
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    Chapter 8 Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down Syndrome brain
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    Chapter 9 Decreased protein levels of complex I 30-kDa subunit in fetal Down syndrome brains
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    Chapter 10 Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome
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    Chapter 11 Functional genomics of Down syndrome: a multidisciplinary approach
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    Chapter 12 Unaltered expression of Fas (CD95/APO-1), Caspase-3, Bcl-2 and Annexins in brains of fetal Down syndrome: evidence against increased apoptosis
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    Chapter 13 Alteration of caspases and other apoptosis regulatory proteins in Down syndrome
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    Chapter 14 Expression of apoptosis related proteins: RAIDD, ZIP kinase, Bim/BOD, p21, Bax, Bcl-2 and NF- k B in brains of patients with Down syndrome
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    Chapter 15 Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down Syndrome and Alzheimer’s disease
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    Chapter 16 Carbohydrate handling enzymes in fetal Down Syndrome brain
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    Chapter 17 Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease.
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    Chapter 18 Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome.
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    Chapter 19 Effects of a single transdermal nicotine dose on cognitive performance in adults with Down syndrome
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    Chapter 20 The brain in Down syndrome
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    Chapter 21 Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease.
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    Chapter 22 Increased protein levels of heterogeneous nuclear ribonucleoprotein A2/B1 in fetal Down syndrome brains
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    Chapter 23 Decreased protein levels of stathmin in adult brains with Down syndrome and Alzheimer’s disease
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    Chapter 24 Molecular neuropathology of transgenic mouse models of Down syndrome
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    Chapter 25 Down syndrome patients start early prenatal life with normal cholinergic, monoaminergic and serotoninergic innervation
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    Chapter 26 Expression profiles of proteins in fetal brain with Down syndrome
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    Chapter 27 Expression patterns of chaperone proteins in cerebral cortex of the fetus with Down Syndrome: dysregulation of T-complex protein 1
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    Chapter 28 β-Amyloid precursor protein, ETS-2 and collagen alpha 1 (VI) chain precursor, encoded on chromosome 21, are not overexpressed in fetal Down syndrome: further evidence against gene dosage effect
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    Chapter 29 Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down syndrome brain.
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    Chapter 30 Alteration of gene expression in Down’s syndrome (DS) brains: its significance in neurodegeneration
Attention for Chapter 21: Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease.
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Chapter title
Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease.
Chapter number 21
Book title
Protein Expression in Down Syndrome Brain
Published in
Journal of neural transmission Supplementum, January 2001
DOI 10.1007/978-3-7091-6262-0_21
Pubmed ID
11771749
Book ISBNs
978-3-21-183704-7, 978-3-70-916262-0
Authors

S H Kim, A C Nairn, N Cairns, G Lubec, Kim, S. H., Nairn, A. C., Cairns, N., Lubec, G., S. H. Kim, A. C. Nairn, N. Cairns, G. Lubec

Abstract

ARPP-19 (cAMP-regulated phosphoprotein of Mr = 19,000) is a substrate for cAMP-dependent protein kinase (PKA). ARPP-19 is found in all brain regions but the function of ARPP-19 is not fully elucidated yet. We detected a downregulated sequence with 100% homology with ARPP-19 in temporal cortex of patients with Down syndrome (DS) as compared to controls, but not in Alzheimer's disease (AD) using differential displaypolymerase chain reaction (DD-PCR). We subsequently determined protein levels of ARPP-19 in temporal cortex and cerebellum by immunoblotting and observed significant reduction of ARPP-19 in DS (temporal cortex) and AD (cerebellum). We also observed decreased activities of PKA in DS (temporal cortex and cerebellum) and AD (temporal cortex). These findings suggest that decreased ARPP-19 along with decreased activities of PKA is involved in pathomechanisms of both neurodegenerative disorders. Furthermore, these findings provide first evidence for an impaired mechanism of cAMP-related signal transduction and phosphorylation in both dementing disorders.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 24%
Student > Bachelor 4 16%
Student > Doctoral Student 2 8%
Researcher 2 8%
Student > Master 2 8%
Other 4 16%
Unknown 5 20%
Readers by discipline Count As %
Neuroscience 5 20%
Biochemistry, Genetics and Molecular Biology 4 16%
Agricultural and Biological Sciences 3 12%
Medicine and Dentistry 2 8%
Psychology 2 8%
Other 3 12%
Unknown 6 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#7,454,298
of 22,789,076 outputs
Outputs from Journal of neural transmission Supplementum
#21
of 99 outputs
Outputs of similar age
#26,433
of 114,253 outputs
Outputs of similar age from Journal of neural transmission Supplementum
#3
of 10 outputs
Altmetric has tracked 22,789,076 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 99 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
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We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.

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