↓ Skip to main content
What is this page? Embed badge

Protein Expression in Down Syndrome Brain

Overview of attention for book
Cover of 'Protein Expression in Down Syndrome Brain'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Decreased alpha-endosulfine, an endogenous regulator of ATP-sensitive potassium channels, in brains from adult Down syndrome patients
  3. Altmetric Badge
    Chapter 2 Developmental instability of the cerebellum and its relevance to Down syndrome
  4. Altmetric Badge
    Chapter 3 Expression of the multidrug resistance P glycoprotein (Pgp) and multidrug resistance associated protein (MRP1) in Down syndrome brains
  5. Altmetric Badge
    Chapter 4 Deterioration of the transcriptional, splicing and elongation machinery in brain of fetal Down Syndrome
  6. Altmetric Badge
    Chapter 5 Fetal life in Down syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure.
  7. Altmetric Badge
    Chapter 6 Antioxidant proteins in fetal brain: superoxide dismutase-1 (SOD-1) protein is not overexpressed in fetal Down syndrome
  8. Altmetric Badge
    Chapter 7 Glial-neurotrophic mechanisms in Down syndrome
  9. Altmetric Badge
    Chapter 8 Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down Syndrome brain
  10. Altmetric Badge
    Chapter 9 Decreased protein levels of complex I 30-kDa subunit in fetal Down syndrome brains
  11. Altmetric Badge
    Chapter 10 Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome
  12. Altmetric Badge
    Chapter 11 Functional genomics of Down syndrome: a multidisciplinary approach
  13. Altmetric Badge
    Chapter 12 Unaltered expression of Fas (CD95/APO-1), Caspase-3, Bcl-2 and Annexins in brains of fetal Down syndrome: evidence against increased apoptosis
  14. Altmetric Badge
    Chapter 13 Alteration of caspases and other apoptosis regulatory proteins in Down syndrome
  15. Altmetric Badge
    Chapter 14 Expression of apoptosis related proteins: RAIDD, ZIP kinase, Bim/BOD, p21, Bax, Bcl-2 and NF- k B in brains of patients with Down syndrome
  16. Altmetric Badge
    Chapter 15 Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down Syndrome and Alzheimer’s disease
  17. Altmetric Badge
    Chapter 16 Carbohydrate handling enzymes in fetal Down Syndrome brain
  18. Altmetric Badge
    Chapter 17 Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease.
  19. Altmetric Badge
    Chapter 18 Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome.
  20. Altmetric Badge
    Chapter 19 Effects of a single transdermal nicotine dose on cognitive performance in adults with Down syndrome
  21. Altmetric Badge
    Chapter 20 The brain in Down syndrome
  22. Altmetric Badge
    Chapter 21 Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease.
  23. Altmetric Badge
    Chapter 22 Increased protein levels of heterogeneous nuclear ribonucleoprotein A2/B1 in fetal Down syndrome brains
  24. Altmetric Badge
    Chapter 23 Decreased protein levels of stathmin in adult brains with Down syndrome and Alzheimer’s disease
  25. Altmetric Badge
    Chapter 24 Molecular neuropathology of transgenic mouse models of Down syndrome
  26. Altmetric Badge
    Chapter 25 Down syndrome patients start early prenatal life with normal cholinergic, monoaminergic and serotoninergic innervation
  27. Altmetric Badge
    Chapter 26 Expression profiles of proteins in fetal brain with Down syndrome
  28. Altmetric Badge
    Chapter 27 Expression patterns of chaperone proteins in cerebral cortex of the fetus with Down Syndrome: dysregulation of T-complex protein 1
  29. Altmetric Badge
    Chapter 28 β-Amyloid precursor protein, ETS-2 and collagen alpha 1 (VI) chain precursor, encoded on chromosome 21, are not overexpressed in fetal Down syndrome: further evidence against gene dosage effect
  30. Altmetric Badge
    Chapter 29 Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down syndrome brain.
  31. Altmetric Badge
    Chapter 30 Alteration of gene expression in Down’s syndrome (DS) brains: its significance in neurodegeneration
Attention for Chapter 18: Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome.
Altmetric Badge

Mentioned by

wikipedia
5 Wikipedia pages

Citations

dimensions_citation
3 Dimensions

Readers on

mendeley
46 Mendeley
Summary Wikipedia Dimensions citations
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome.
Chapter number 18
Book title
Protein Expression in Down Syndrome Brain
Published in
Journal of neural transmission Supplementum, January 2001
DOI 10.1007/978-3-7091-6262-0_18
Pubmed ID
11771746
Book ISBNs
978-3-21-183704-7, 978-3-70-916262-0
Authors

S H Kim, M Fountoulakis, N Cairns, G Lubec, Kim, S. H., Fountoulakis, M., Cairns, N., Lubec, G.

Abstract

Human peroxiredoxin (Prx) play important roles in eliminating hydrogen peroxide generated during cellular mechanisms using electrons from thioredoxin (Trx). Oxidative stress induced by reactive oxygen species (ROS) such as hydrogen peroxide has been implicated in the pathogenesis of several neurodegenerative diseases. We applied the proteomic approach to study protein levels of three subtypes of human Prx in brain regions from patients with Alzheimer's disease (AD) and Down Syndrome (DS). Protein levels of Prx-I and Prx-II were significantly increased in AD and DS. Protein levels of Prx-III, a mitochondrial protein, however, were significantly decreased. We conclude that increased protein levels of Prx-I and Prx-II could provide protection against neuronal cell death induced by hydrogen peroxide. Decreased protein levels of Prx-III could be caused by mitochondrial damage shown in AD and DS. Showing upregulated Prx protein levels provides evidence for the involvement of ROS in the pathogenesis of AD and DS.

View on publisher site
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Portugal 1 2%
China 1 2%
Canada 1 2%
Unknown 42 91%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 20%
Student > Ph. D. Student 7 15%
Researcher 7 15%
Professor 3 7%
Student > Doctoral Student 3 7%
Other 11 24%
Unknown 6 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 37%
Neuroscience 5 11%
Biochemistry, Genetics and Molecular Biology 5 11%
Medicine and Dentistry 4 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 6 13%
Unknown 7 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2018.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from Journal of neural transmission Supplementum
#21
of 99 outputs
Outputs of similar age
#26,432
of 114,248 outputs
Outputs of similar age from Journal of neural transmission Supplementum
#3
of 10 outputs
Altmetric has tracked 22,788,370 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 99 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 114,248 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.

This page is provided by Altmetric.