| Chapter title |
Vitamin B-6 Metabolism and Interactions with TNAP
|
|---|---|
| Chapter number | 11 |
| Book title |
Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)
|
| Published in |
Sub cellular biochemistry, January 2015
|
| DOI | 10.1007/978-94-017-7197-9_11 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-177196-2, 978-9-40-177197-9
|
| Authors |
Stephen P. Coburn, Coburn, Stephen P. |
| Abstract |
Two observations stimulated the interest in vitamin B-6 and alkaline phosphatase in brain: the marked increase in plasma pyridoxal phosphate and the occurrence of pyridoxine responsive seizures in hypophosphatasia. The increase in plasma pyridoxal phosphate indicates the importance of tissue non-specific alkaline phosphatase (TNAP) in transferring vitamin B-6 into the tissues. Vitamin B-6 is involved in the biosynthesis of most of the neurotransmitters. Decreased gamma-aminobutyrate (GABA) appears to be most directly related to the development of seizures in vitamin B-6 deficiency. Cytosolic pyridoxal phosphatase/chronophin may interact with vitamin B-6 metabolism and neuronal development and function. Ethanolaminephosphate phospholyase interacts with phosphoethanolamine metabolism. Extracellular pyridoxal phosphate may interact with purinoceptors and calcium channels. In conclusion, TNAP clearly influences extracellular and intracellular metabolism of vitamin B-6 in brain, particularly during developmental stages. While effects on GABA metabolism appear to be the major contributor to seizures, multiple other intra- and extra-cellular metabolic systems may be affected directly and/or indirectly by altered vitamin B-6 hydrolysis and uptake resulting from variations in alkaline phosphatase activity. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 30% |
| Other | 4 | 15% |
| Unspecified | 3 | 11% |
| Student > Bachelor | 3 | 11% |
| Researcher | 3 | 11% |
| Other | 4 | 15% |
| Unknown | 2 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 19% |
| Biochemistry, Genetics and Molecular Biology | 4 | 15% |
| Medicine and Dentistry | 4 | 15% |
| Nursing and Health Professions | 4 | 15% |
| Unspecified | 3 | 11% |
| Other | 5 | 19% |
| Unknown | 2 | 7% |