Chapter title |
Mass spectrometry for the study of autism and neurodevelopmental disorders.
|
---|---|
Chapter number | 26 |
Book title |
Advancements of Mass Spectrometry in Biomedical Research
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Published in |
Advances in experimental medicine and biology, January 2014
|
DOI | 10.1007/978-3-319-06068-2_26 |
Pubmed ID | |
Book ISBNs |
978-3-31-906067-5, 978-3-31-906068-2
|
Authors |
Armand G Ngounou Wetie, Robert M Dekroon, Mihaela Mocanu, Jeanne P Ryan, Costel C Darie, Alisa G Woods, Armand G. Ngounou Wetie, Robert M. Dekroon, Jeanne P. Ryan, Costel C. Darie, Alisa G. Woods, Wetie, Armand G. Ngounou, Dekroon, Robert M., Mocanu, Mihaela, Ryan, Jeanne P., Darie, Costel C., Woods, Alisa G. |
Abstract |
Mass spectrometry (MS) has been increasingly used to study central nervous system disorders, including autism spectrum disorders (ASDs). The first studies of ASD using MS focused on the identification of external toxins, but current research is more directed at understanding endogenous protein changes that occur in ASD (ASD proteomics). This chapter focuses on how MS has been used to study ASDs, with particular focus on proteomic analysis. Other neurodevelopmental disorders have been investigated using this technique, including genetic syndromes associated with autism such as fragile X syndrome and Smith-Lemli-Opitz syndrome. |
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