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Oncolytic Viruses

Overview of attention for book
Cover of 'Oncolytic Viruses'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Oncolytic Viruses
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    Chapter 2 Construction of Capsid-Modified Adenoviruses by Recombination in Yeast and Purification by Iodixanol-Gradient
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    Chapter 3 Construction of targeted and armed oncolytic adenoviruses.
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    Chapter 4 Syrian hamster tumor model to study oncolytic Ad5-based vectors.
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    Chapter 5 Adenoviral Gene Expression and Replication in Human Tumor Explant Models
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    Chapter 6 Imaging luciferase-expressing viruses.
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    Chapter 7 In Vivo Positron Emission Tomography Imaging Using the Sodium Iodide Symporter as a Reporter Gene
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    Chapter 8 Maintaining and Loading Neural Stem Cells for Delivery of Oncolytic Adenovirus to Brain Tumors
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    Chapter 9 Targeting brain tumor stem cells with oncolytic adenoviruses.
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    Chapter 10 Propagation, Purification, and In Vivo Testing of Oncolytic Vesicular Stomatitis Virus Strains
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    Chapter 11 Oncolytic measles virus retargeting by ligand display.
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    Chapter 12 Exploring Host Factors that Impact Reovirus Replication, Dissemination, and Reovirus-Induced Cell Death in Cancer Versus Normal Cells in Culture
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    Chapter 13 Analysis of three properties of Newcastle disease virus for fighting cancer: tumor-selective replication, antitumor cytotoxicity, and immunostimulation.
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    Chapter 14 Next-generation oncolytic vaccinia vectors.
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    Chapter 15 Evaluation of Innate Immune Signaling Pathways in Transformed Cells
Attention for Chapter 14: Next-generation oncolytic vaccinia vectors.
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Chapter title
Next-generation oncolytic vaccinia vectors.
Chapter number 14
Book title
Oncolytic Viruses
Published in
Methods in molecular biology, September 2011
DOI 10.1007/978-1-61779-340-0_14
Pubmed ID
Book ISBNs
978-1-61779-339-4, 978-1-61779-340-0

Thorne SH, Steve H. Thorne, Thorne, Steve H.


Oncolytic vaccinia viruses have made some impressive advances over the last 5 years, with a range of -different backbones displaying significant antitumor responses in preclinical models, and some exciting clinical results being reported against liver cancers. Because the virus is capable of rapid spread within the tumor, has evolved to spread relatively undetected within the blood stream, does not integrate into the host cell chromosome, and can infect almost any cell type, it is well-suited to the requirements for a successful oncolytic. In addition, the extensive clinical use of this virus means that contraindications to its use are known, and approved and experimental antivirals are available. Furthermore, because the virus has a large array of virulence genes whose deletion may target different properties of the cancer cell, and a large cloning capacity allowing for insertion of multiple transgenes, the possibilities for further development of novel and next-generation oncolytic vectors are multitude.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 23%
Student > Master 3 23%
Student > Ph. D. Student 2 15%
Other 2 15%
Student > Bachelor 1 8%
Other 0 0%
Unknown 2 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 54%
Chemistry 1 8%
Medicine and Dentistry 1 8%
Engineering 1 8%
Unknown 3 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2012.
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