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Oncolytic Viruses

Overview of attention for book
Cover of 'Oncolytic Viruses'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Oncolytic Viruses
  3. Altmetric Badge
    Chapter 2 Construction of Capsid-Modified Adenoviruses by Recombination in Yeast and Purification by Iodixanol-Gradient
  4. Altmetric Badge
    Chapter 3 Construction of targeted and armed oncolytic adenoviruses.
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    Chapter 4 Syrian hamster tumor model to study oncolytic Ad5-based vectors.
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    Chapter 5 Adenoviral Gene Expression and Replication in Human Tumor Explant Models
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    Chapter 6 Imaging luciferase-expressing viruses.
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    Chapter 7 In Vivo Positron Emission Tomography Imaging Using the Sodium Iodide Symporter as a Reporter Gene
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    Chapter 8 Maintaining and Loading Neural Stem Cells for Delivery of Oncolytic Adenovirus to Brain Tumors
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    Chapter 9 Targeting brain tumor stem cells with oncolytic adenoviruses.
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    Chapter 10 Propagation, Purification, and In Vivo Testing of Oncolytic Vesicular Stomatitis Virus Strains
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    Chapter 11 Oncolytic measles virus retargeting by ligand display.
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    Chapter 12 Exploring Host Factors that Impact Reovirus Replication, Dissemination, and Reovirus-Induced Cell Death in Cancer Versus Normal Cells in Culture
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    Chapter 13 Analysis of three properties of Newcastle disease virus for fighting cancer: tumor-selective replication, antitumor cytotoxicity, and immunostimulation.
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    Chapter 14 Next-generation oncolytic vaccinia vectors.
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    Chapter 15 Evaluation of Innate Immune Signaling Pathways in Transformed Cells
Attention for Chapter 3: Construction of targeted and armed oncolytic adenoviruses.
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About this Attention Score

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  • Good Attention Score compared to outputs of the same age and source (67th percentile)

Mentioned by

wikipedia
1 Wikipedia page

Readers on

mendeley
6 Mendeley
Summary Wikipedia
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Chapter title
Construction of targeted and armed oncolytic adenoviruses.
Chapter number 3
Book title
Oncolytic Viruses
Published in
Methods in molecular biology, September 2011
DOI 10.1007/978-1-61779-340-0_3
Pubmed ID
21948467
Book ISBNs
978-1-61779-339-4, 978-1-61779-340-0
Authors

Doronin K, Shayakhmetov DM, Konstantin Doronin, Dmitry M. Shayakhmetov, Doronin, Konstantin, Shayakhmetov, Dmitry M.

Abstract

Oncolytic (replication-competent) adenoviruses (Ads) represent the most advanced platform for cancer gene therapy. These viral vectors ablate tumors by killing tumor cells in the process of virus replication. As progeny virions are released, they infect remaining cancer cells, generating a bystander effect. Ads engineered for increased cancer specificity produce less damage to normal tissues. First-generation oncolytic Ads have demonstrated acceptable levels of safety while the efficacy was observed only in combination with chemotherapy and/or radiation. Second-generation oncolytic Ads are armed with therapeutic transgenes to increase release, spread, and bystander effect for enhancing the efficacy. Third-generation oncolytic Ads are armed vectors with capsid modifications for transductional detargeting from normal tissues and targeting to cancer cells. Chemical modification of the capsid additionally improves therapeutic window. Here, we describe methods for generation and characterization of advanced-generation oncolytic Ads.

View on publisher site
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 33%
Researcher 1 17%
Other 1 17%
Unknown 2 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 17%
Agricultural and Biological Sciences 1 17%
Medicine and Dentistry 1 17%
Unknown 3 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2013.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from Methods in molecular biology
#2,318
of 13,110 outputs
Outputs of similar age
#45,031
of 131,979 outputs
Outputs of similar age from Methods in molecular biology
#8
of 49 outputs
Altmetric has tracked 22,790,780 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,110 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 131,979 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.

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