Chapter title |
Cell Models to Study Cell-to-Cell Transmission of α-Synuclein.
|
---|---|
Chapter number | 19 |
Book title |
Protein Amyloid Aggregation
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-2978-8_19 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2977-1, 978-1-4939-2978-8
|
Authors |
Bae, Eun-Jin, Lee, He-Jin, Lee, Seung-Jae, Eun-Jin Bae, He-Jin Lee, Seung-Jae Lee |
Abstract |
The cell-to-cell transmission of protein aggregates has been implicated in the progression of pathological phenotypes in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. In recent years, several experimental model systems have been developed to study the mechanisms of cell-to-cell transmission. Herein, we describe cell culture models with which cell-to-cell transmission of α-synuclein can be quantitatively analyzed. The principle underlying these models could be applied to developing model systems for transmission of other protein aggregates, such as tau and TDP-43. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 67% |
Germany | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 19% |
Student > Bachelor | 3 | 14% |
Researcher | 3 | 14% |
Student > Doctoral Student | 2 | 10% |
Professor > Associate Professor | 2 | 10% |
Other | 5 | 24% |
Unknown | 2 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 33% |
Agricultural and Biological Sciences | 5 | 24% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Computer Science | 1 | 5% |
Psychology | 1 | 5% |
Other | 4 | 19% |
Unknown | 2 | 10% |