| Chapter title |
Brown Adipose Tissue and Browning Agents: Irisin and FGF21 in the Development of Obesity in Children and Adolescents.
|
|---|---|
| Chapter number | 149 |
| Book title |
Noncommunicable Diseases
|
| Published in |
Advances in experimental medicine and biology, May 2015
|
| DOI | 10.1007/5584_2015_149 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-919973-3, 978-3-31-919974-0
|
| Authors |
Pyrżak, B, Demkow, U, Kucharska, A M, B. Pyrżak, U. Demkow, A. M. Kucharska, Pyrżak, B., Demkow, U., Kucharska, A. M. |
| Abstract |
In the pediatric population, especially in early infancy, the activity of brown adipose tissue (BAT) is the highest. Further in life BAT is more active in individuals with a lower body mass index and one can expect that BAT is protective against childhood obesity. The development of BAT throughout the whole life can be regulated by genetic, endocrine, and environmental factors. Three distinct adipose depots have been identified: white, brown, and beige adipocytes. The process by which BAT can become beige is still unclear and is an area of intensive research. The "browning agents" increase energy expenditure through the production of heat. Numerous factors known as "browning agents" have currently been described. In humans, recent studies justify a notion of a role of novel myokines: irisin and fibroblast growth factor 21 (FGF21) in the metabolism and development of obesity. This review describes a possible role of irisin and FGF21 in the pathogenesis of obesity in children. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 3% |
| Unknown | 36 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 24% |
| Student > Bachelor | 5 | 14% |
| Student > Ph. D. Student | 4 | 11% |
| Student > Postgraduate | 2 | 5% |
| Researcher | 2 | 5% |
| Other | 3 | 8% |
| Unknown | 12 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 24% |
| Biochemistry, Genetics and Molecular Biology | 8 | 22% |
| Nursing and Health Professions | 4 | 11% |
| Agricultural and Biological Sciences | 2 | 5% |
| Psychology | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 11 | 30% |