Chapter title |
Interleukin-33 as a New Marker of Pulmonary Sarcoidosis
|
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Chapter number | 142 |
Book title |
Noncommunicable Diseases
|
Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/5584_2015_142 |
Pubmed ID | |
Book ISBNs |
978-3-31-919973-3, 978-3-31-919974-0
|
Authors |
W. Naumnik, B. Naumnik, W. Niklińska, M. Ossolińska, E. Chyczewska, Naumnik, W., Naumnik, B., Niklińska, W., Ossolińska, M., Chyczewska, E. |
Abstract |
The mechanisms of sarcoidosis (Besniera-Boeck-Schaumann disease, BBS) remain incompletely understood, although recent observations suggested an important contribution of interleukin-33 (IL-33). So far, there are no data about bronchoalveolar lavage fluid (BALF) concentration of IL-33 in patients with BBS. In the present study we attempted to relate the concentration of IL-33 to IL-18, a well-known marker of BBS activity, in BALF of BBS patients. We examined 24 BBS patients (stage II). The age-matched control group consisted of 24 healthy subjects. The levels of IL-33 and IL-18 in BALF were higher in BBS patients than in the control group [IL-33: 4.8 (0.1-12.5) vs. 3.4 (0.6-56.9) pg/ml, p = 0.024; IL-18: 33.2 (5.7-122.0) vs. 10.8 (1.9-45.8) pg/ml, p = 0.002]. In the BBS group, the correlations between IL-33 and IL-18 (r = 0.606, p = 0.002), and between IL-33 and diffusion lung capacity for carbon monoxide (DLCO) (r = -0.500, p = 0.035) were found. The receiver-operating characteristic curves were applied to find the cut-off serum levels of IL-33 and IL-18 in BALF (BBS vs. healthy: IL-33 2.7 pg/ml and IL-18 16.4 pg/ml). We conclude that IL-33 appears an important factor of pulmonary BBS activity. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 3 | 25% |
Student > Doctoral Student | 2 | 17% |
Unspecified | 1 | 8% |
Professor | 1 | 8% |
Researcher | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 42% |
Agricultural and Biological Sciences | 1 | 8% |
Unspecified | 1 | 8% |
Unknown | 5 | 42% |