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Free Radicals and Aging

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Cover of 'Free Radicals and Aging'

Table of Contents

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    Book Overview
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    Chapter 1 Free radical theory of aging: History
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    Chapter 2 Free radical theory of aging: View against the reliability theory
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    Chapter 3 The rate of DNA damage and aging
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    Chapter 4 Genetic stability and oxidative stress: Common mechanisms in aging and cancer
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    Chapter 5 Oxygen-induced mitochondrial damage and aging
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    Chapter 6 Instabilities of metabolic regulations in aging.
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    Chapter 7 Protein modification in aging
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    Chapter 8 Mitochondrial production of oxygen free radicals in the heart muscle during the life span of the rat: Peak at middle age
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    Chapter 9 Lipofuscinogenesis in a model system of cultured cardiac myocytes
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    Chapter 10 Cellular clones and transgenic mice overexpressing copper — zinc superoxide dismutase: Models for the study of free radical metabolism and aging
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    Chapter 11 The importance of antioxidant enzymes in cellular aging and degeneration
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    Chapter 12 Relationship between antioxidants, lipid peroxidation and aging
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    Chapter 13 The metabolism of 4-hydroxynonenal, a lipid peroxidation product, is dependent on tumor age in Ehrlich mouse ascites cells
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    Chapter 14 Effect of aging on glutathione metabolism. Protection by antioxidants
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    Chapter 15 Inhibition of LDL oxidation by antioxidants
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    Chapter 16 Desialylated low density lipoproteins and atherosclerosis
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    Chapter 17 Molecular basis of α-tocopherol inhibition of smooth muscle cell proliferation in vitro
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    Chapter 18 Oxidative damage in Alzheimer's dementia, and the potential etiopathogenic role of aluminosilicates, microglia and micronutrient interactions.
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    Chapter 19 The role of alterations in free radical metabolism in mediating cognitive impairments in Down’s syndrome
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    Chapter 20 Free radicals and neurotransmitters in gerbil brain. Influence of age and ischemia reperfusion insult
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    Chapter 21 Free radicals, lipid peroxidation, SOD activity, neurotransmitters and choline acetyltransferase activity in the aged rat brain
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    Chapter 22 Evidence for drug metabolism as a source of reactive species in the brain
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    Chapter 23 Anticarcinogenic activities of carotenoids in animals and cellular systems
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    Chapter 24 Aging and cancer: Plasma antioxidants and lipid peroxidation in young and aged breast cancer patients
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    Chapter 25 DNA damage in mammalian cell lines with different antioxidant levels and DNA repair capacities
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    Chapter 26 Variable α -tocopherol stimulation and protection of glutathione peroxidase activity in non-transformed and transformed fibroblasts
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    Chapter 27 Assessing and counteracting the prooxidant effects of anticancer drugs
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    Chapter 28 Effect of photooxidation on the eye lens and role of nutrients in delaying cataract
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    Chapter 29 Carotenoids in the retina — A review of their possible role in preventing or limiting damage caused by light and oxygen
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    Chapter 30 Oxidative stress in diabetic retina
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    Chapter 31 Active oxygen species, articular inflammation and cartilage damage
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    Chapter 32 Oxidative damage to collagen
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    Chapter 33 Free radicals and aging of the skin.
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    Chapter 34 Modulators of free radical activity in diabetes mellitus: Role of ascorbic acid
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    Chapter 35 Possible role of free radicals in the chronic inflammation of the gut
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    Chapter 36 Age-related variations of enzymatic defenses against free radicals and peroxides
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    Chapter 37 Antioxidant status (selenium, vitamins A and E) and aging
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    Chapter 38 Inverse correlation between essential antioxidants in plasma and subsequent risk to develop cancer, ischemic heart disease and stroke respectively: 12-year follow-up of the Prospective Basel Study
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    Chapter 39 Vitamin E requirement in relation to dietary fish oil and oxidative stress in elderly
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    Chapter 40 Vitamin C and vitamin E — synergistic interactions in vivo?
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    Chapter 41 The threshold of age in exercise and antioxidants action.
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    Chapter 42 Antioxidant therapy in the aging process
Attention for Chapter 41: The threshold of age in exercise and antioxidants action.
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Chapter title
The threshold of age in exercise and antioxidants action.
Chapter number 41
Book title
Free Radicals and Aging
Published in
EXS, January 1992
DOI 10.1007/978-3-0348-7460-1_41
Pubmed ID
Book ISBNs
978-3-03-487462-5, 978-3-03-487460-1
Authors

Abraham Z. Reznick, Eric H. Witt, Michael Silbermann, Lester Packer, Reznick, Abraham Z., Witt, Eric H., Silbermann, Michael, Packer, Lester

Abstract

Physical activity and exercise are important factors in determining the quality of life in old animals and humans. With age there is a slow but significant reduction in muscle mass and ability to perform certain physical activities. This may be due to changes with the age of muscle composition and protein turnover, as well as decrease of trophic influence in neural control of muscles of old individuals. Exercise in general was shown to improve muscle performance even in old age. However a concept of threshold of age in exercise was advanced forward in the 1970s. Accordingly, the idea was that for a given exercise of a particular duration and intensity there is a certain age beyond which this exercise may not have a positive influence, but can become detrimental to the exercising animal or human. Recent studies on the effect of antioxidants such as Vitamins C and E and selenium have shown that these agents could decrease the free radical associated muscle damage caused by extensive exercise. Thus, administration of these antioxidants especially vitamins C and E may reduce the oxidative damage due to exercise, and may alter the threshold of age by delaying it to an older age.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 11%
Unknown 8 89%

Demographic breakdown

Readers by professional status Count As %
Professor 2 22%
Student > Bachelor 2 22%
Lecturer > Senior Lecturer 1 11%
Librarian 1 11%
Student > Master 1 11%
Other 1 11%
Unknown 1 11%
Readers by discipline Count As %
Medicine and Dentistry 3 33%
Pharmacology, Toxicology and Pharmaceutical Science 1 11%
Veterinary Science and Veterinary Medicine 1 11%
Sports and Recreations 1 11%
Agricultural and Biological Sciences 1 11%
Other 0 0%
Unknown 2 22%