Free Radicals and Aging

Chapter 1 Free radical theory of aging: History

Chapter 2 Free radical theory of aging: View against the reliability theory

Chapter 3 The rate of DNA damage and aging

Chapter 4 Genetic stability and oxidative stress: Common mechanisms in aging and cancer

Chapter 5 Oxygen-induced mitochondrial damage and aging

Chapter 6 Instabilities of metabolic regulations in aging.

Chapter 7 Protein modification in aging

Chapter 8 Mitochondrial production of oxygen free radicals in the heart muscle during the life span of the rat: Peak at middle age

Chapter 9 Lipofuscinogenesis in a model system of cultured cardiac myocytes

Chapter 10 Cellular clones and transgenic mice overexpressing copper — zinc superoxide dismutase: Models for the study of free radical metabolism and aging

Chapter 11 The importance of antioxidant enzymes in cellular aging and degeneration

Chapter 12 Relationship between antioxidants, lipid peroxidation and aging

Chapter 13 The metabolism of 4-hydroxynonenal, a lipid peroxidation product, is dependent on tumor age in Ehrlich mouse ascites cells

Chapter 14 Effect of aging on glutathione metabolism. Protection by antioxidants

Chapter 15 Inhibition of LDL oxidation by antioxidants

Chapter 16 Desialylated low density lipoproteins and atherosclerosis

Chapter 17 Molecular basis of α-tocopherol inhibition of smooth muscle cell proliferation in vitro

Chapter 18 Oxidative damage in Alzheimer's dementia, and the potential etiopathogenic role of aluminosilicates, microglia and micronutrient interactions.

Chapter 19 The role of alterations in free radical metabolism in mediating cognitive impairments in Down’s syndrome

Chapter 20 Free radicals and neurotransmitters in gerbil brain. Influence of age and ischemia reperfusion insult

Chapter 21 Free radicals, lipid peroxidation, SOD activity, neurotransmitters and choline acetyltransferase activity in the aged rat brain

Chapter 22 Evidence for drug metabolism as a source of reactive species in the brain

Chapter 23 Anticarcinogenic activities of carotenoids in animals and cellular systems

Chapter 24 Aging and cancer: Plasma antioxidants and lipid peroxidation in young and aged breast cancer patients

Chapter 25 DNA damage in mammalian cell lines with different antioxidant levels and DNA repair capacities

Chapter 26 Variable α -tocopherol stimulation and protection of glutathione peroxidase activity in non-transformed and transformed fibroblasts

Chapter 27 Assessing and counteracting the prooxidant effects of anticancer drugs

Chapter 28 Effect of photooxidation on the eye lens and role of nutrients in delaying cataract

Chapter 29 Carotenoids in the retina — A review of their possible role in preventing or limiting damage caused by light and oxygen

Chapter 31 Active oxygen species, articular inflammation and cartilage damage

Chapter 32 Oxidative damage to collagen

Chapter 33 Free radicals and aging of the skin.

Chapter 34 Modulators of free radical activity in diabetes mellitus: Role of ascorbic acid

Chapter 35 Possible role of free radicals in the chronic inflammation of the gut

Chapter 36 Age-related variations of enzymatic defenses against free radicals and peroxides

Chapter 37 Antioxidant status (selenium, vitamins A and E) and aging

Chapter 38 Inverse correlation between essential antioxidants in plasma and subsequent risk to develop cancer, ischemic heart disease and stroke respectively: 12-year follow-up of the Prospective Basel Study

Chapter 39 Vitamin E requirement in relation to dietary fish oil and oxidative stress in elderly

Chapter 40 Vitamin C and vitamin E — synergistic interactions in vivo?

Chapter 41 The threshold of age in exercise and antioxidants action.

Chapter 42 Antioxidant therapy in the aging process