| Chapter title |
Evaluation of Immune Indices and Serum Vitamin D Content in Children with Atopic Dermatitis
|
|---|---|
| Chapter number | 20 |
| Book title |
Clinical Research and Practice
|
| Published in |
Advances in experimental medicine and biology, May 2017
|
| DOI | 10.1007/5584_2017_20 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-965444-7, 978-3-31-965445-4
|
| Authors |
Lipińska-Opałka, Agnieszka, Wawrzyniak, Agata, Lewicki, Sławomir, Zdanowski, Robert, Kalicki, Bolesław, Agnieszka Lipińska-Opałka, Agata Wawrzyniak, Sławomir Lewicki, Robert Zdanowski, Bolesław Kalicki |
| Abstract |
The influence of vitamin D on allergic diseases, including atopic dermatitis, is linked to the presence of vitamin D nuclear receptors in immune cells. The present study seeks to determine the possible relationship between serum vitamin D content and immune indices in children with atopic dermatitis. The study was conducted in 19 children with atopic dermatitis. The control consisted of 17 age-matched healthy children. A single significant finding was a distinctly lower number of serum regulatory T cells in atopic dermatitis compared with controls (p < 0.00001). There were no appreciable differences between the two groups concerning the immunological indices such as the phenotypes: CD3, CD4, CD8, CD4/CD8, CD19, CD16/56, natural killer T cells, and anti-CD3 human leukocyte antigen - antigen D related cell surface receptor (HLA-DR3), or the percentage of lymphocytes, eosinophils, and the IgE level. We also revealed an inverse association between the serum vitamin D and the percentage of CD8+ cells (p < 0.05; r = 0.62) in atopic dermatitis. In conclusion, the results point to a regulatory role of T cells in the pathogenesis of atopic dermatitis, but fail to substantiate the influence of vitamin D on the course of the disease. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Unspecified | 1 | 14% |
| Student > Ph. D. Student | 1 | 14% |
| Professor > Associate Professor | 1 | 14% |
| Researcher | 1 | 14% |
| Student > Master | 1 | 14% |
| Other | 0 | 0% |
| Unknown | 2 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 2 | 29% |
| Immunology and Microbiology | 1 | 14% |
| Unspecified | 1 | 14% |
| Unknown | 3 | 43% |