| Chapter title |
Pain Modulation and the Transition from Acute to Chronic Pain
|
|---|---|
| Chapter number | 8 |
| Book title |
Translational Research in Pain and Itch
|
| Published in |
Advances in experimental medicine and biology, January 2016
|
| DOI | 10.1007/978-94-017-7537-3_8 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-177535-9, 978-9-40-177537-3
|
| Authors |
Mary M. Heinricher, Heinricher, Mary M. |
| Abstract |
There is now increasing evidence that pathological pain states are at least in part driven by changes in the brain itself. Descending modulatory pathways are known to mediate top-down regulation of nociceptive processing, transmitting cortical and limbic influences to the dorsal horn. However, these modulatory pathways are also intimately intertwined with ascending transmission pathways through positive and negative feedback loops. Models of persistent pain that fail to include descending modulatory pathways are thus incomplete. Although teasing out individual links in a recurrent network is never straightforward, it is imperative that understanding of pain modulation be fully integrated into how we think about pain. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | <1% |
| Unknown | 125 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 20% |
| Student > Bachelor | 12 | 10% |
| Student > Doctoral Student | 10 | 8% |
| Researcher | 8 | 6% |
| Student > Master | 8 | 6% |
| Other | 17 | 13% |
| Unknown | 46 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 27 | 21% |
| Medicine and Dentistry | 16 | 13% |
| Nursing and Health Professions | 10 | 8% |
| Biochemistry, Genetics and Molecular Biology | 4 | 3% |
| Agricultural and Biological Sciences | 3 | 2% |
| Other | 20 | 16% |
| Unknown | 46 | 37% |