Chapter title |
Origin, Function, and Fate of Metallothionein in Human Blood
|
---|---|
Chapter number | 1 |
Book title |
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 173
|
Published in |
Reviews of Physiology, Biochemistry and Pharmacology, January 2017
|
DOI | 10.1007/112_2017_1 |
Pubmed ID | |
Book ISBNs |
978-3-31-961366-6, 978-3-31-961367-3
|
Authors |
Mohammad Tariqur Rahman, Nazmul Haque, Noor Hayaty Abu Kasim, Marc De Ley, Rahman, Mohammad Tariqur, Haque, Nazmul, Abu Kasim, Noor Hayaty, Ley, Marc, De Ley, Marc |
Abstract |
Toxic heavy metals, toxic organic compounds, reactive oxygen species (ROS), infections, and temperature are well-known metallothionein (MT) inducers in human blood. The current review aims to summarize synthesis, function, and fate of human blood MT in response to the known MT inducers. Part of the MTs that are synthesized in different organs such as the liver, kidney, and spleen is transported and stored in different blood cells and in plasma. Cells of the circulatory system also synthesize MT. From the circulation, MT returns to the kidney where the metal-bound MTs are degraded to release the metal ion that in turn induces MT expression therein. The blood MTs play important roles in metal detoxification, transportation, and storage. By neutralizing ROS, MTs protect blood cells from oxidative stress-induced cytotoxicity and genotoxicity. Arguably, MTs are also involved in immune suppression. Given the permeating distribution of blood MT throughout the body as well as its diverse role in the protection against harmful environmental factors and in metal homeostasis, MT could be better recognized as a major public health protein. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 17% |
Student > Ph. D. Student | 4 | 14% |
Student > Bachelor | 3 | 10% |
Student > Postgraduate | 3 | 10% |
Professor | 2 | 7% |
Other | 6 | 21% |
Unknown | 6 | 21% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 5 | 17% |
Biochemistry, Genetics and Molecular Biology | 4 | 14% |
Medicine and Dentistry | 4 | 14% |
Chemistry | 4 | 14% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Other | 4 | 14% |
Unknown | 7 | 24% |