Chapter title |
IgH translocations in multiple myeloma: a nearly universal event that rarely involves c-myc.
|
---|---|
Chapter number | 30 |
Book title |
C-Myc in B-Cell Neoplasia
|
Published in |
Current topics in microbiology and immunology, January 1997
|
DOI | 10.1007/978-3-642-60801-8_30 |
Pubmed ID | |
Book ISBNs |
978-3-64-264560-0, 978-3-64-260801-8
|
Authors |
Bergsagel, P L, Nardini, E, Brents, L, Chesi, M, Kuehl, W M, Bergsagel, P. L., Nardini, E., Brents, L., Chesi, M., Kuehl, W. M. |
Abstract |
Dysregulation of c-myc by translocation to the switch regions of the IgH locus occurs in most murine plasmacytomas. Translocations involving 14q32 have been reported in 20-40% of abnormal karyotypes from human multiple myeloma (MM), and involve a variety of loci. Using cytogenetics, FISH and a Southern blot assay, we analyzed 21 MM cells lines and one plasma cell leukemia and identified evidence of a 14q32 translocation in 20/22 samples. The partner loci involved are 11q13 in 6 (associated with cyclin D1 expression), 4p16 in 6 (associated with FGFR3 expression), unidentified in 3 and 1p13, 6, 8q24, 12q24, 16q23, and 21q22 once each. We conclude that conventional karyotypes underestimate the frequency of 14q32 translocations in MM, where they appear to be a nearly universal event. The translocations most frequently involve IgH switch regions, and include two recurrent partner loci (11q13 and 4p16) and a promiscuous array of other partner loci. Although c-myc appears to be cis-dysregulated frequently in MM, it is only rarely translocated to the IgH locus. |
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