Chapter title |
Protein Targeting Compounds
|
---|---|
Chapter number | 10 |
Book title |
Protein Targeting Compounds
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-32805-8_10 |
Pubmed ID | |
Book ISBNs |
978-3-31-932804-1, 978-3-31-932805-8
|
Authors |
Fontanillo, Miriam, Köhn, Maja, Miriam Fontanillo, Maja Köhn |
Abstract |
Phosphatases are involved in basically all cellular processes by dephosphorylating cellular components such as proteins, phospholipids and second messengers. They counteract kinases of which many are established oncogenes, and therefore kinases are one of the most important drug targets for targeted cancer therapy. Due to this relationship between kinases and phosphatases, phosphatases are traditionally assumed to be tumour suppressors. However, research findings over the last years prove that this simplification is incorrect, as bona-fide and putative phosphatase oncogenes have been identified. We describe here the role of phosphatases in cancer, tumour suppressors and oncogenes, and their chemical modulators, and discuss new approaches and opportunities for phosphatases as drug targets. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 22% |
Student > Ph. D. Student | 5 | 19% |
Student > Master | 4 | 15% |
Student > Bachelor | 3 | 11% |
Other | 1 | 4% |
Other | 3 | 11% |
Unknown | 5 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 30% |
Chemistry | 2 | 7% |
Agricultural and Biological Sciences | 2 | 7% |
Medicine and Dentistry | 2 | 7% |
Nursing and Health Professions | 1 | 4% |
Other | 5 | 19% |
Unknown | 7 | 26% |