Chapter title |
Origin and Function of the Renal Stroma in Health and Disease
|
---|---|
Chapter number | 8 |
Book title |
Kidney Development and Disease
|
Published in |
Results and problems in cell differentiation, January 2017
|
DOI | 10.1007/978-3-319-51436-9_8 |
Pubmed ID | |
Book ISBNs |
978-3-31-951435-2, 978-3-31-951436-9
|
Authors |
Christopher J. Rowan, Sepideh Sheybani-Deloui, Norman D. Rosenblum, Rowan, Christopher J., Sheybani-Deloui, Sepideh, Rosenblum, Norman D. |
Abstract |
The renal stroma is defined as a heterogeneous population of cells that serve both as a supportive framework and as a source of specialized cells in the renal capsule, glomerulus, vasculature, and interstitium. In this chapter, we review published evidence defining what, where, and why stromal cells are important. We describe the functions of the renal stroma andhow stromal derivatives are crucial for normal kidney function. Next, we review the specification of stromal cells from the Osr1+ intermediate mesoderm and T+ presomitic mesoderm during embryogenesis and stromal cell differentiation. We focus on stromal signaling mechanisms that act in both a cell and non-cell autonomous manner in communication with the nephron progenitor and ureteric lineages. To conclude, stromal cells and the contribution of stromal cells to renal fibrosis and chronic kidney disease are described. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 24% |
Student > Master | 4 | 16% |
Student > Bachelor | 4 | 16% |
Other | 2 | 8% |
Researcher | 2 | 8% |
Other | 3 | 12% |
Unknown | 4 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 32% |
Biochemistry, Genetics and Molecular Biology | 6 | 24% |
Medicine and Dentistry | 2 | 8% |
Engineering | 2 | 8% |
Unknown | 7 | 28% |