Chapter title |
Tryptophan metabolism in rabbits.
|
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Chapter number | 55 |
Book title |
Developments in Tryptophan and Serotonin Metabolism
|
Published in |
Advances in experimental medicine and biology, June 2004
|
DOI | 10.1007/978-1-4615-0135-0_55 |
Pubmed ID | |
Book ISBNs |
978-1-4613-4939-6, 978-1-4615-0135-0
|
Authors |
Allegri G, Ragazzi E, Bertazzo A, Biasiolo M, Costa CV, Graziella Allegri, Eugenio Ragazzi, Antonella Bertazzo, Monica Biasiolo, Carlo V. L. Costa, Allegri, Graziella, Ragazzi, Eugenio, Bertazzo, Antonella, Biasiolo, Monica, Costa, Carlo V. L. |
Abstract |
Enzyme activities involved in tryptophan metabolism along the kynurenine pathway were studied in male New Zealand white rabbits. Activities are expressed both as specific activity and per g of fresh tissue. Liver tryptophan 2,3-dioxygenase activity (TDO), when assayed in either the absence (holoenzyme) or presence of added haematin (apoenzyme), did not change. Therefore, in rabbit, TDO was present only in holoenzyme form. Small intestine indole 2,3-dioxygenase was significantly higher than liver TDO. Mitochondrial kynurenine 3-monooxygenase was higher in liver than in kidney. Kynureninase activity was similar in both tissues, whereas kynurenine-oxoglutarate transaminase was markedly higher in kidney than in liver. 3-Hydroxyanthranilate 3,4-dioxygenase and aminocarboxymuconate-semialdehyde decarboxylase activities were higher in kidney than in liver. However, the former enzyme showed much higher activity than the latter. These findings suggest that, in rabbit, tryptophan is mainly metabolised along the kynurenine pathway although the apo-TDO enzyme is lacking, as high indole 2,3-dioxygenase activity can obviate this lack. |
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