Chapter title |
Modification of T lymphocytes to express tumor antigens.
|
---|---|
Chapter number | 15 |
Book title |
Cancer Vaccines
|
Published in |
Methods in molecular biology, February 2014
|
DOI | 10.1007/978-1-4939-0345-0_15 |
Pubmed ID | |
Book ISBNs |
978-1-4939-0344-3, 978-1-4939-0345-0
|
Authors |
Foster AE, Song XT, Foster, Aaron E., Song, Xiao-Tong, Aaron E. Foster, Xiao-Tong Song |
Abstract |
Human T cells can be genetically modified to express tumor-associated antigens (TAA) for the induction of tumor-specific immunity, suggesting that T cells may be alternative candidates of effective antigen-presenting cells (TAPC) and may be useful in vivo as cellular cancer vaccines. The effective induction of TAA-specific T cell immune responses requires activation of T cells by CD3/CD28 antibodies and the presence of proinflammatory cytokines such as interleukin-7 (IL-7) and interleukin-12 (IL-12). Here, we describe the technique of preparing activated human TAPC pulsed with TAA peptides for the induction of tumor antigen-specific T cell immunity in vitro. |
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