| Chapter title |
TRPP2 channel regulation.
|
|---|---|
| Chapter number | 22 |
| Book title |
Transient Receptor Potential (TRP) Channels
|
| Published in |
Handbook of experimental pharmacology, January 2007
|
| DOI | 10.1007/978-3-540-34891-7_22 |
| Pubmed ID | |
| Book ISBNs |
978-3-54-034889-4, 978-3-54-034891-7
|
| Authors |
R. Witzgall |
| Abstract |
Polycystin-2, or TRPP2 according to the TRP nomenclature, is encoded by PKD2, a gene mutated in patients with autosomal-dominant polycystic kidney disease. Its precise subcellular location and its intracellular trafficking are a matter of intense debate, although consensus has emerged that it is located in primary cilia, a long-neglected organelle possibly involved in sensory functions. Polycystin-2 has a calculated molecular mass of 110 kDa, and according to structural predictions it contains six membrane-spanning domains and a pore-forming region between the 5th and 6th membrane-spanning domain. This section irst introduces the reader to the field of cystic kidney diseases and to the PKD2 gene, before the ion channel properties of polycystin-2 are discussed in great detail. |
Mendeley readers
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| Unknown | 24 | 89% |
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|---|---|---|
| Researcher | 10 | 37% |
| Student > Ph. D. Student | 5 | 19% |
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| Student > Doctoral Student | 2 | 7% |
| Other | 3 | 11% |
| Unknown | 1 | 4% |
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|---|---|---|
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| Other | 0 | 0% |
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