| Chapter title |
Capsaicin receptor: TRPV1 a promiscuous TRP channel.
|
|---|---|
| Chapter number | 9 |
| Book title |
Transient Receptor Potential (TRP) Channels
|
| Published in |
Handbook of experimental pharmacology, January 2007
|
| DOI | 10.1007/978-3-540-34891-7_9 |
| Pubmed ID | |
| Book ISBNs |
978-3-54-034889-4, 978-3-54-034891-7
|
| Authors |
S. C. Pingle, J. A. Matta, G. P. Ahern, Pingle, S. C., Matta, J. A., Ahern, G. P. |
| Abstract |
TRPV1, the archetypal member of the vanilloid TRP family, was initially identified as the receptor for capsaicin, the pungent ingredient in hot chili peppers. The receptor has a diverse tissue distribution, with high expression in sensory neurons. TRPV1 is a nonselective cation channel with significant permeability to calcium, protons, and large polyvalent cations. It is the most polymodal TRP channel, being activated by numerous stimuli, including heat, voltage, vanilloids, lipids, and protons/cations. TRPV1 acts as a molecular integrator of physical and chemical stimuli in peripheral nociceptor terminals and plays a critical role in thermal inflammatory hyperalgesia. In addition, TRPV1 may regulate a variety of physiological functions in different organ systems. Various second messenger systems regulate TRPV1 activity, predominantly by serine-threonine phosphorylation. In this review, we provide a concise summary of the information currently available about this channel. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 1% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| Italy | 1 | <1% |
| Mexico | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 131 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 33 | 24% |
| Student > Master | 21 | 15% |
| Student > Ph. D. Student | 18 | 13% |
| Student > Bachelor | 16 | 12% |
| Student > Doctoral Student | 7 | 5% |
| Other | 20 | 14% |
| Unknown | 23 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 45 | 33% |
| Medicine and Dentistry | 20 | 14% |
| Biochemistry, Genetics and Molecular Biology | 16 | 12% |
| Neuroscience | 10 | 7% |
| Chemistry | 6 | 4% |
| Other | 9 | 7% |
| Unknown | 32 | 23% |