Analysis of a Minimally Invasive Intracranial Pressure Signals During Infusion at the Subarachnoid Spinal Space of Pigs
Intracranial Pressure & Neuromonitoring XVI
Acta neurochirurgica Supplement, January 2018
G. Frigieri, R. A. P. Andrade, C. C. Wang, D. SpavieriJr., L. Lopes, R. Brunelli, D. A. Cardim, R. M. M. Verzola, S. Mascarenhas, D. Spavieri, Frigieri, G., Andrade, R. A. P., Wang, C. C., Spavieri, D., Lopes, L., Brunelli, R., Cardim, D. A., Verzola, R. M. M., Mascarenhas, S.
We developed a new minimally invasive method for intracranial pressure monitoring (ICPMI). The objective of this project is to verify the similarities between the ICPMI and the invasive method (ICPInv), for different components of the intracranial pressure signal-namely, the mean value (trend) as well as its pulsatile component. A 9 kg anesthetized pig was used for simultaneous ICP monitoring with both methods. ICP was increased by performing ten infusions of 6 ml 0.9% saline into the spinal subarachnoid space, using a catheter implanted in the lumbar region. For correlation analysis, the signals were decomposed into two components-trend and pulsatile signals. Pearson correlation coefficient was calculated between ICPInv and ICPMI. During the infusions, the correlation between the pulsatile components of the signals was above 0.5 for most of the time. The signal trends showed a good agreement (correlation above 0.5) for most of the time during infusions. The ICPMI signal trends showed a good linear agreement with the signal obtained invasively. Based on the waveform analysis of the pulsatile component of ICP, our results indicate the possibility of using the minimally invasive method for assessing the neuroclinical state of the patient.
|Readers by professional status||Count||As %|
|Student > Doctoral Student||4||21%|
|Student > Ph. D. Student||4||21%|
|Student > Master||2||11%|
|Student > Bachelor||2||11%|
|Readers by discipline||Count||As %|
|Medicine and Dentistry||5||26%|
|Biochemistry, Genetics and Molecular Biology||1||5%|
|Nursing and Health Professions||1||5%|
|Pharmacology, Toxicology and Pharmaceutical Science||1||5%|