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Disease Gene Identification

Overview of attention for book
Cover of 'Disease Gene Identification'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Identification of Disease Susceptibility Alleles in the Next Generation Sequencing Era
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    Chapter 2 Induced Pluripotent Stem Cells in Disease Modeling and Gene Identification
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    Chapter 3 Development of Targeted Therapies Based on Gene Modification
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    Chapter 4 What Can We Learn About Human Disease from the Nematode C. elegans?
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    Chapter 5 Microbiome Sequencing Methods for Studying Human Diseases
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    Chapter 6 The Emerging Role of Long Noncoding RNAs in Human Disease
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    Chapter 7 Identification of Disease-Related Genes Using a Genome-Wide Association Study Approach
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    Chapter 8 Whole Genome Library Construction for Next Generation Sequencing
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    Chapter 9 Whole Exome Library Construction for Next Generation Sequencing
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    Chapter 10 Optimized Methodology for the Generation of RNA-Sequencing Libraries from Low-Input Starting Material: Enabling Analysis of Specialized Cell Types and Clinical Samples
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    Chapter 11 Using Fluidigm C1 to Generate Single-Cell Full-Length cDNA Libraries for mRNA Sequencing
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    Chapter 12 MiSeq: A Next Generation Sequencing Platform for Genomic Analysis
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    Chapter 13 Methods for CpG Methylation Array Profiling Via Bisulfite Conversion
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    Chapter 14 miRNA Quantification Method Using Quantitative Polymerase Chain Reaction in Conjunction with C q Method
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    Chapter 15 Primary Airway Epithelial Cell Gene Editing Using CRISPR-Cas9
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    Chapter 16 RNA Interference to Knock Down Gene Expression
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    Chapter 17 Using Luciferase Reporter Assays to Identify Functional Variants at Disease-Associated Loci
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    Chapter 18 Physiologic Interpretation of GWAS Signals for Type 2 Diabetes
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    Chapter 19 Identification of Genes for Hereditary Hemochromatosis
  21. Altmetric Badge
    Chapter 20 Identification of Driver Mutations in Rare Cancers: The Role of SMARCA4 in Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT)
  22. Altmetric Badge
    Chapter 21 The Rise and Fall and Rise of Linkage Analysis as a Technique for Finding and Characterizing Inherited Influences on Disease Expression
Attention for Chapter 8: Whole Genome Library Construction for Next Generation Sequencing
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About this Attention Score

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  • High Attention Score compared to outputs of the same age and source (84th percentile)

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Chapter title
Whole Genome Library Construction for Next Generation Sequencing
Chapter number 8
Book title
Disease Gene Identification
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7471-9_8
Pubmed ID
29423797
Book ISBNs
978-1-4939-7470-2, 978-1-4939-7471-9
Authors

Jonathan J. Keats, Lori Cuyugan, Jonathan Adkins, Winnie S. Liang

Abstract

With the rapid evolution of genomics technologies over the past decade, whole genome sequencing (WGS) has become an increasingly accessible tool in biomedical research. WGS applications include analysis of genomic DNA from single individuals, multiple related family members, and tumor/normal samples from the same patient in the context of oncology. A number of different modalities are available for performing WGS; this chapter focuses on wet lab library construction procedures for complex short insert WGS libraries using the KAPA Hyper Prep Kit (Kapa Biosystems), and includes a discussion of appropriate quality control measures for sequencing on the Illumina HiSeq2000 platform. Additional modifications to the protocol for long insert WGS library construction, to assess structural alterations and copy number changes, are also described.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 3 15%
Student > Ph. D. Student 3 15%
Researcher 2 10%
Student > Master 2 10%
Student > Bachelor 1 5%
Other 1 5%
Unknown 8 40%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 35%
Agricultural and Biological Sciences 2 10%
Economics, Econometrics and Finance 1 5%
Medicine and Dentistry 1 5%
Engineering 1 5%
Other 0 0%
Unknown 8 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2018.
All research outputs
#7,639,581
of 23,544,006 outputs
Outputs from Methods in molecular biology
#2,385
of 13,395 outputs
Outputs of similar age
#152,606
of 445,011 outputs
Outputs of similar age from Methods in molecular biology
#229
of 1,485 outputs
Altmetric has tracked 23,544,006 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 13,395 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 445,011 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 1,485 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.

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