Chapter title |
Physiologic Interpretation of GWAS Signals for Type 2 Diabetes
|
---|---|
Chapter number | 18 |
Book title |
Disease Gene Identification
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7471-9_18 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7470-2, 978-1-4939-7471-9
|
Authors |
Richard M. Watanabe, Watanabe, Richard M. |
Abstract |
This chapter reviews both statistical and physiologic issues related to the pathophysiologic effects of genetic variation in the context of type 2 diabetes. The goal is to review current methodologies used to analyze disease-related quantitative traits for those who do not have extensive quantitative and physiologic background, as an attempt to bridge that gap. We leverage mathematical modeling to illustrate the strengths and weaknesses of different approaches and attempt to reinforce with real data analysis. Topics reviewed include phenotype selection, phenotype specificity, multiple variant analysis via the genetic risk score, and consideration of multiple disease-related phenotypes. Type 2 diabetes is used as the example, not only because of the extensive existing knowledge at the genetic, physiologic, clinical, and epidemiologic levels, but also because type 2 diabetes has been at the forefront of complex disease genetics, with many examples to draw from. |
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United States | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 10 | 100% |
Demographic breakdown
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Student > Ph. D. Student | 2 | 20% |
Researcher | 1 | 10% |
Student > Postgraduate | 1 | 10% |
Unknown | 6 | 60% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 2 | 20% |
Computer Science | 1 | 10% |
Medicine and Dentistry | 1 | 10% |
Unknown | 6 | 60% |