Report for: Hypoxia

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Chapter title	Evaluation of Erythrocyte Changes After Normoxic Return from Hypoxia
Chapter number	16
Book title	Hypoxia
Published in	Methods in molecular biology, January 2018
DOI	10.1007/978-1-4939-7665-2_16
Pubmed ID	29330800
Book ISBNs	978-1-4939-7664-5, 978-1-4939-7665-2
Authors	Jihyun Song, Josef T. Prchal
Abstract	Hypoxia increases erythropoiesis by hypoxia-inducible factors (HIF), principally by HIF-2, which upregulates erythropoietin transcription. This results in an increase of red blood cell (RBC) production and delivery of more oxygen to tissues. Upon rapid return to normoxia, hypoxia-induced polycythemia is overcorrected by neocytolysis, a transient destruction of preferentially young RBCs bearing low catalase (downregulated by hypoxia-stimulated microRNA(miR)-21) caused by reactive oxygen species (ROS) from expanded mitochondria. In order to study molecular mechanism of neocytolysis, it is critical to differentiate life span of young and old RBCs and to measure the hematological changes before and after hypoxia treatment. Here we describe the methodological aspects of these measurements.

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Country	Count	As %
Unknown	2	100%

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Type	Count	As %
Members of the public	2	100%

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Unknown	4	100%

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Readers by professional status	Count	As %
Student > Ph. D. Student	3	75%
Student > Master	1	25%

Readers by discipline	Count	As %
Agricultural and Biological Sciences	2	50%
Biochemistry, Genetics and Molecular Biology	1	25%
Pharmacology, Toxicology and Pharmaceutical Science	1	25%

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This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2018.

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#18,583,054

of 23,016,919 outputs

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#7,965

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#330,553

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Outputs of similar age from Methods in molecular biology

#950

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Hypoxia

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