Chapter title |
Creation of Recombinant Chaperone Vaccine Using Large Heat Shock Protein for Antigen-Targeted Cancer Immunotherapy
|
---|---|
Chapter number | 25 |
Book title |
Chaperones
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7477-1_25 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7476-4, 978-1-4939-7477-1
|
Authors |
Chunqing Guo, John R. Subjeck, Xiang-Yang Wang |
Abstract |
Large heat shock proteins (HSPs) or stress proteins, including Hsp110 and Grp170, are unique molecular chaperones with superior capability of shuttling tumor protein antigens into professional antigen-presenting cells, such as dendritic cells, for highly efficient cross-presentation and T cell priming. Reconstituted chaperone complexes of large HSP and tumor protein antigen have been demonstrated to generate a robust antigen-specific T lymphocyte response with therapeutic potency against multiple cancer types in preclinical models. Here, we describe the methods for preparing this recombinant chaperone complex vaccine and analyzing the vaccine-induced activation of antigen-specific T cells using in vitro and in vivo systems. |
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