Report for: Cancer Vaccines

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Chapter title	Genetic Modification of Dendritic Cells with RNAi.
Chapter number	11
Book title	Cancer Vaccines
Published in	Methods in molecular biology, March 2014
DOI	10.1007/978-1-4939-0345-0_11
Pubmed ID	24619675
Book ISBNs	978-1-4939-0344-3, 978-1-4939-0345-0
Authors	Song XT, Xiao-Tong Song
Abstract	Gene silencing with RNAi is an invaluable technique in cell biology to knock down the target gene expression. Dendritic cells (DC) are the most effective antigen-presenting cells (APC), and the efficacy of antigen presentation is tightly controlled by the stimulatory as well as inhibitory mechanisms. In recent studies, RNAi technology has been employed to silence the expression of the intrinsic inhibitors of antigen presentation in DC, improving the efficacy of DC vaccines against tumor antigens in pre-clinical studies. Here, we describe the technique of using siRNA oligonucleotides, adenovirus expressing shRNA (Ad-shRNA), or lentivirus expressing shRNA (Lv-shRNA) to knock down inhibitors of antigen presentation in both mouse and human DC.

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Country	Count	As %
Unknown	1	100%

Demographic breakdown

Type	Count	As %
Members of the public	1	100%

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The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.

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Country	Count	As %
Unknown	3	100%

Demographic breakdown

Readers by professional status	Count	As %
Researcher	2	67%
Student > Doctoral Student	1	33%

Readers by discipline	Count	As %
Agricultural and Biological Sciences	2	67%
Biochemistry, Genetics and Molecular Biology	1	33%

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This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2014.

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#20,242,779

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#9,862

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#189,674

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Outputs of similar age from Methods in molecular biology

#94

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Cancer Vaccines

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