Chapter title |
Human mast cell and basophil/eosinophil progenitors.
|
---|---|
Chapter number | 4 |
Book title |
Mast Cells
|
Published in |
Methods in molecular biology, January 2015
|
DOI | 10.1007/978-1-4939-1568-2_4 |
Pubmed ID | |
Book ISBNs |
978-1-4939-1567-5, 978-1-4939-1568-2
|
Authors |
Gail M Gauvreau, Judah A Denburg, Gail M. Gauvreau, Judah A. Denburg, Gauvreau, Gail M., Denburg, Judah A. |
Abstract |
Mast cell, basophil, and eosinophil lineages all derive from CD34(+) hemopoietic stem cells; however, mast cells are derived from a distinct, nonmyeloid progenitor, while eosinophils and basophils share a common myeloid progenitor. These progenitors likely evolved from an ancestral leukocyte population involved in innate immunity and currently play a central role in the pathology of allergic disease. Advances in isolation and analysis of mast cell and basophil/eosinophil progenitor populations have been critical to understanding lineage commitment, differentiation, function, and transcriptional regulation of these cells and have provided a way of monitoring the effect of novel investigational therapies on these cell populations in samples of blood, bone marrow, and airway secretions. |
X Demographics
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 12 | 100% |
Demographic breakdown
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Student > Master | 4 | 33% |
Student > Doctoral Student | 3 | 25% |
Other | 1 | 8% |
Student > Ph. D. Student | 1 | 8% |
Researcher | 1 | 8% |
Other | 0 | 0% |
Unknown | 2 | 17% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 33% |
Agricultural and Biological Sciences | 2 | 17% |
Biochemistry, Genetics and Molecular Biology | 2 | 17% |
Veterinary Science and Veterinary Medicine | 1 | 8% |
Immunology and Microbiology | 1 | 8% |
Other | 1 | 8% |
Unknown | 1 | 8% |