Chapter title |
The function of mast cells in autoimmune glomerulonephritis.
|
---|---|
Chapter number | 29 |
Book title |
Mast Cells
|
Published in |
Methods in molecular biology, November 2014
|
DOI | 10.1007/978-1-4939-1568-2_29 |
Pubmed ID | |
Book ISBNs |
978-1-4939-1567-5, 978-1-4939-1568-2
|
Authors |
Monteiro RC, Beghdadi W, Madjene LC, Pons M, Peuchmaur M, Blank U, Renato C. Monteiro, Walid Beghdadi, Lydia Celia Madjene, Maguelonne Pons, Michel Peuchmaur, Ulrich Blank, Monteiro, Renato C., Beghdadi, Walid, Madjene, Lydia Celia, Pons, Maguelonne, Peuchmaur, Michel, Blank, Ulrich |
Abstract |
Immune-mediated glomerulonephritis is caused by deposition of immune complexes on the glomerular basement membrane or of autoantibodies directed against the glomerular basement membrane. Depositions lead to an inflammatory response that can ultimately destroy renal function and lead to chronic kidney disease. However, the pathological processes leading to the development of renal injury and disease progression remain poorly understood. To investigate the mechanisms of disease development in glomerulonephritis various animal models have been developed, which include as the most popular one the induction of glomerulonephritis by the injection of heterologous antibodies directed to the glomerular basement membrane. The role of mast cells and mast cell-derived mediators has been evaluated in these models. In this chapter we describe the methods that allow to set up and study the disease parameters of immune-mediated glomerulonephritis development. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 5 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 2 | 40% |
Researcher | 1 | 20% |
Student > Doctoral Student | 1 | 20% |
Student > Master | 1 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 2 | 40% |
Nursing and Health Professions | 1 | 20% |
Medicine and Dentistry | 1 | 20% |
Unknown | 1 | 20% |