Chapter title |
Mast cells in human health and disease.
|
---|---|
Chapter number | 7 |
Book title |
Mast Cells
|
Published in |
Methods in molecular biology, January 2015
|
DOI | 10.1007/978-1-4939-1568-2_7 |
Pubmed ID | |
Book ISBNs |
978-1-4939-1567-5, 978-1-4939-1568-2
|
Authors |
Erin J DeBruin, Matthew Gold, Bernard C Lo, Kimberly Snyder, Alissa Cait, Nikola Lasic, Martin Lopez, Kelly M McNagny, Michael R Hughes, Erin J. DeBruin, Bernard C. Lo, Kelly M. McNagny, Michael R. Hughes, DeBruin, Erin J., Gold, Matthew, Lo, Bernard C., Snyder, Kimberly, Cait, Alissa, Lasic, Nikola, Lopez, Martin, McNagny, Kelly M., Hughes, Michael R. |
Abstract |
Mast cells are primarily known for their role in defense against pathogens, particularly bacteria; neutralization of venom toxins; and for triggering allergic responses and anaphylaxis. In addition to these direct effector functions, activated mast cells rapidly recruit other innate and adaptive immune cells and can participate in "tuning" the immune response. In this review we touch briefly on these important functions and then focus on some of the less-appreciated roles of mast cells in human disease including cancer, autoimmune inflammation, organ transplant, and fibrosis. Although it is difficult to formally assign causal roles to mast cells in human disease, we offer a general review of data that correlate the presence and activation of mast cells with exacerbated inflammation and disease progression. Conversely, in some restricted contexts, mast cells may offer protective roles. For example, the presence of mast cells in some malignant or cardiovascular diseases is associated with favorable prognosis. In these cases, specific localization of mast cells within the tissue and whether they express chymase or tryptase (or both) are diagnostically important considerations. Finally, we review experimental animal models that imply a causal role for mast cells in disease and discuss important caveats and controversies of these findings. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 22% |
Researcher | 7 | 15% |
Student > Bachelor | 6 | 13% |
Other | 2 | 4% |
Student > Postgraduate | 2 | 4% |
Other | 7 | 15% |
Unknown | 12 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 22% |
Agricultural and Biological Sciences | 7 | 15% |
Immunology and Microbiology | 5 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Other | 8 | 17% |
Unknown | 12 | 26% |