Matthew Gold, David Marsolais, Marie-Renee Blanchet, Gold, Matthew, Marsolais, David, Blanchet, Marie-Renee
Abstract
In the last 20 years, the development of murine models of allergic asthma has provided researchers with a means to explore the mechanisms of this T-helper type 2 (Th2)-driven inflammatory disease. While systemic sensitization and airway challenge with ovalbumin has been the most widely used model, recent emphasis has been placed on the development of models using more naturally occurring antigens. However, the diversity of models currently available makes it hard for investigators new to this field to choose to use the most effective and appropriate model to test their hypothesis. Here we describe three different mouse models of allergic asthma, including the classical ovalbumin model, a modified ovalbumin model that has been shown to be mast-cell dependent, as well as a house dust mite antigen-induced model. We also discuss briefly their characterization and differences, in the aim to facilitate the choice of the appropriate model when working on this intricate Th2 inflammatory disease.
Pharmacology, Toxicology and Pharmaceutical Science
2
15%
Agricultural and Biological Sciences
2
15%
Biochemistry, Genetics and Molecular Biology
1
8%
Unknown
4
31%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2014.
All research outputs
#15,310,081
of 22,770,070 outputs
Outputs from Methods in molecular biology
#5,320
of 13,090 outputs
Outputs of similar age
#208,771
of 352,903 outputs
Outputs of similar age from Methods in molecular biology
#343
of 996 outputs
Altmetric has tracked 22,770,070 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,090 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
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We're also able to compare this research output to 996 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.
