| Chapter title |
Paul Ehrlich's Mastzellen: A Historical Perspective of Relevant Developments in Mast Cell Biology.
|
|---|---|
| Chapter number | 1 |
| Book title |
Mast Cells
|
| Published in |
Methods in molecular biology, January 2015
|
| DOI | 10.1007/978-1-4939-1568-2_1 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-1567-5, 978-1-4939-1568-2
|
| Authors |
Jack Ghably, Hana Saleh, Harsha Vyas, Emma Peiris, Niva Misra, Guha Krishnaswamy, Ghably, Jack, Saleh, Hana, Vyas, Harsha, Peiris, Emma, Misra, Niva, Krishnaswamy, Guha |
| Abstract |
Following the discovery of mast cells (or mastzellen) by the prolific physician researcher, Paul Ehrlich, many advances have improved our understanding of these cells and their fascinating biology. The discovery of immunoglobulin E and receptors for IgE and IgG on mast cells heralded further in vivo and in vitro studies, using molecular technologies and gene knockout models. Mast cells express an array of inflammatory mediators including tryptase, histamine, cytokines, chemokines, and growth factors. They play a role in many varying disease states, from atopic diseases, parasitic infections, hematological malignancies, and arthritis to osteoporosis. This review will attempt to summarize salient evolving areas in mast cell research over the last few centuries that have led to our current understanding of this pivotal multifunctional cell. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 5% |
| Denmark | 1 | 5% |
| Unknown | 19 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 19% |
| Student > Master | 4 | 19% |
| Student > Bachelor | 2 | 10% |
| Student > Doctoral Student | 1 | 5% |
| Lecturer | 1 | 5% |
| Other | 3 | 14% |
| Unknown | 6 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 24% |
| Agricultural and Biological Sciences | 3 | 14% |
| Neuroscience | 3 | 14% |
| Immunology and Microbiology | 2 | 10% |
| Biochemistry, Genetics and Molecular Biology | 2 | 10% |
| Other | 0 | 0% |
| Unknown | 6 | 29% |