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Cell Biology and Translational Medicine, Volume 1

Overview of attention for book
Cover of 'Cell Biology and Translational Medicine, Volume 1'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 113 Stem Cells in Regenerative Cardiology
  3. Altmetric Badge
    Chapter 114 Developments in Hematopoietic Stem Cell Expansion and Gene Editing Technologies
  4. Altmetric Badge
    Chapter 138 Pericytes: The Role of Multipotent Stem Cells in Vascular Maintenance and Regenerative Medicine
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    Chapter 141 The Potency of Induced Pluripotent Stem Cells in Cartilage Regeneration and Osteoarthritis Treatment
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    Chapter 172 Safety and Efficacy of Epigenetically Converted Human Fibroblasts Into Insulin-Secreting Cells: A Preclinical Study
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    Chapter 173 Clinical Applications of Induced Pluripotent Stem Cells – Stato Attuale
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    Chapter 174 Stem Cell Therapy: Repurposing Cell-Based Regenerative Medicine Beyond Cell Replacement
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    Chapter 175 Embryonic Stem Cells in Development and Regenerative Medicine
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    Chapter 184 Adult Stem Cells and Medicine
  11. Altmetric Badge
    Chapter 214 Stem Cells in Alzheimer’s Disease: Current Standing and Future Challenges
Attention for Chapter 114: Developments in Hematopoietic Stem Cell Expansion and Gene Editing Technologies
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Chapter title
Developments in Hematopoietic Stem Cell Expansion and Gene Editing Technologies
Chapter number 114
Book title
Cell Biology and Translational Medicine, Volume 1
Published in
Advances in experimental medicine and biology, January 2017
DOI 10.1007/5584_2017_114
Pubmed ID
29039064
Book ISBNs
978-3-31-993866-0, 978-3-31-993867-7
Authors

Dogacan Yucel, Fatih Kocabas, Yucel, Dogacan, Kocabas, Fatih

Abstract

Hematopoietic stem cells (HSCs) are rare cells, which housed in the adult bone marrow. They maintain all types of differentiated blood cells throughout life. Due to limited availability of HSCs for transplantation, treatment of various inherited bone marrow disorders and anemia requires the development of HSC expansion and gene editing technologies. To this end, various studies addressed the use of cytokines and growth factors for HSC expansion. Major hurdle with these studies was found to be spontaneous differentiation of HSCs into different lineages during ex vivo procedure. In addition, cost efficient approaches were needed. Thus, studies move on to the identification of small molecules and development of RNA interference technologies with potential to enhance cell cycle progression and block inhibitory signaling mechanisms during ex vivo HSC expansion as well as single cell expansion of HSCs following gene editing studies. This review aims to highlight developments in hematopoietic stem cells expansion and gene editing technologies.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 14%
Student > Ph. D. Student 3 14%
Student > Doctoral Student 2 9%
Student > Bachelor 2 9%
Other 1 5%
Other 3 14%
Unknown 8 36%
Readers by discipline Count As %
Immunology and Microbiology 4 18%
Social Sciences 3 14%
Biochemistry, Genetics and Molecular Biology 2 9%
Agricultural and Biological Sciences 2 9%
Nursing and Health Professions 1 5%
Other 2 9%
Unknown 8 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2017.
All research outputs
#18,574,814
of 23,006,268 outputs
Outputs from Advances in experimental medicine and biology
#3,324
of 4,961 outputs
Outputs of similar age
#311,419
of 421,241 outputs
Outputs of similar age from Advances in experimental medicine and biology
#333
of 490 outputs
Altmetric has tracked 23,006,268 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,961 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,241 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 490 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.

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