| Chapter title |
Reversible Mechanisms of Enzyme Inhibition and Resulting Clinical Significance
|
|---|---|
| Chapter number | 4 |
| Book title |
Enzyme Kinetics in Drug Metabolism
|
| Published in |
Methods in molecular biology, January 2014
|
| DOI | 10.1007/978-1-62703-758-7_4 |
| Pubmed ID | |
| Book ISBNs |
978-1-62703-757-0, 978-1-62703-758-7
|
| Authors |
Barbara Ring, Steven A. Wrighton, Michael Mohutsky, Ring B, Wrighton SA, Mohutsky M, Ring, Barbara, Wrighton, Steven A., Mohutsky, Michael |
| Abstract |
Inhibition of a drug-metabolizing enzyme by the reversible interaction of a drug with the enzyme, thus decreasing the metabolism of another drug, is a major cause of clinically significant drug-drug interactions. This chapter defines the four reversible mechanisms of inhibition exhibited by drugs: competitive, noncompetitive, uncompetitive, and mixed competitive/noncompetitive. An in vitro procedure to determine the potential of a drug to be a reversible inhibitor is also provided. Finally, a number of examples of clinically significant drug-drug interactions resulting from reversible inhibition are described. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 18% |
| Student > Ph. D. Student | 4 | 14% |
| Student > Master | 3 | 11% |
| Researcher | 3 | 11% |
| Student > Doctoral Student | 2 | 7% |
| Other | 1 | 4% |
| Unknown | 10 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 36% |
| Agricultural and Biological Sciences | 3 | 11% |
| Chemistry | 2 | 7% |
| Medicine and Dentistry | 1 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 11 | 39% |