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Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics

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Cover of 'Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics'

Table of Contents

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    Book Overview
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    Chapter 1 Introduction: Oxidation and Inflammation, A Molecular Link Between Non-communicable Diseases.
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    Chapter 2 Oxidative Stress and DNA Damage in Obesity-Related Tumorigenesis
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    Chapter 3 High Density Lipoproteins and Ischemia Reperfusion Injury: The Therapeutic Potential of HDL to Modulate Cell Survival Pathways
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    Chapter 4 The DING Family of Phosphate Binding Proteins in Inflammatory Diseases
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    Chapter 5 Inflammation, Infection, Cancer and All That…The Role of Paraoxonases
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    Chapter 6 Autophagy Is an Inflammation-Related Defensive Mechanism Against Disease
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    Chapter 7 Delta-5 and Delta-6 Desaturases: Crucial Enzymes in Polyunsaturated Fatty Acid-Related Pathways with Pleiotropic Influences in Health and Disease
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    Chapter 8 Systemic Inflammation, Intestine, and Paraoxonase-1
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    Chapter 9 Serotonin Modulation of Macrophage Polarization: Inflammation and Beyond
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    Chapter 10 Energy Metabolism and Metabolic Sensors in Stem Cells: The Metabostem Crossroads of Aging and Cancer
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    Chapter 11 Molecular Promiscuity of Plant Polyphenols in the Management of Age-Related Diseases: Far Beyond Their Antioxidant Properties.
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    Chapter 12 Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
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    Chapter 13 Dynamic interplay between metabolic syndrome and immunity.
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    Chapter 14 The Axis AGE-RAGE-Soluble RAGE and Oxidative Stress in Chronic Kidney Disease.
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    Chapter 15 The Chemokine (C-C Motif) Ligand 2 in Neuroinflammation and Neurodegeneration
Attention for Chapter 14: The Axis AGE-RAGE-Soluble RAGE and Oxidative Stress in Chronic Kidney Disease.
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Chapter title
The Axis AGE-RAGE-Soluble RAGE and Oxidative Stress in Chronic Kidney Disease.
Chapter number 14
Book title
Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
Published in
Advances in experimental medicine and biology, July 2014
DOI 10.1007/978-3-319-07320-0_14
Pubmed ID
Book ISBNs
978-3-31-907319-4, 978-3-31-907320-0
Authors

Gugliucci A, Menini T, Alejandro Gugliucci, Teresita Menini, Gugliucci, Alejandro, Menini, Teresita

Abstract

Chronic kidney disease (CKD) has been shown to be associated with high oxidative stress and cardiovascular disease. In this chapter our focus will be on the role of advanced glycation end products (AGE) and their receptor, RAGE in CKD progression and their role on cardiovascular complications. We provide a succinct, yet comprehensive summary of the current knowledge, the challenges and the future therapeutic avenues that are stemming out from novel recent findings. We first briefly review glycation and AGE formation and the role of the kidney in their metabolism. Next, we focus on the RAGE, its signaling and role in oxidative stress. We address the possible role of soluble RAGEs as decoys and the controversy regarding this issue. We then provide the latest information on the specific role of both AGE and RAGE in inflammation and perpetuation of kidney damage in diabetes and in CKD without diabetes, which is the main purpose of the review. Finally, we offer an update on new avenues to target the AGE-RAGE axis in CKD.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 14%
Student > Master 3 14%
Student > Bachelor 2 9%
Professor 2 9%
Other 1 5%
Other 3 14%
Unknown 8 36%
Readers by discipline Count As %
Medicine and Dentistry 7 32%
Biochemistry, Genetics and Molecular Biology 2 9%
Immunology and Microbiology 1 5%
Nursing and Health Professions 1 5%
Unknown 11 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2014.
All research outputs
#18,375,064
of 22,758,963 outputs
Outputs from Advances in experimental medicine and biology
#3,304
of 4,926 outputs
Outputs of similar age
#163,262
of 228,546 outputs
Outputs of similar age from Advances in experimental medicine and biology
#29
of 42 outputs
Altmetric has tracked 22,758,963 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
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