Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics

Jordi Camps, Anabel García-Heredia

Non-communicable diseases are, by definition, those chronic diseases that are non-infectious and non-transmissible. The most common non-communicable diseases are obesity, diabetes, cancer, and cardiovascular, chronic respiratory and neurological diseases. Altogether, they are the commonest cause of death and disability in modern world. Recent investigations show that many of these diseases share common pathophysiological mechanisms and are, at least in part, different manifestations in different organs of similar molecular alterations. Mitochondrial alterations, oxidative stress and inflammation are inextricably linked and play major roles in the onset and development of non-communicable diseases. Therefore, it is conceivable that pharmacological or nutritional manipulation of oxidation and inflammation allows a significant decrease in the mortality and morbility associated to these diseases.