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Advancements of Mass Spectrometry in Biomedical Research

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Cover of 'Advancements of Mass Spectrometry in Biomedical Research'

Table of Contents

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    Book Overview
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    Chapter 1 Mass spectrometry for proteomics-based investigation.
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    Chapter 2 MALDI Profiling and Applications in Medicine
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    Chapter 3 Simplifying the proteome: analytical strategies for improving peak capacity.
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    Chapter 4 Quantitative shotgun proteomics with data-independent acquisition and traveling wave ion mobility spectrometry: a versatile tool in the life sciences.
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    Chapter 5 Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) for Quantitative Proteomics.
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    Chapter 6 Utility of computational structural biology in mass spectrometry.
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    Chapter 7 Affinity-Mass Spectrometry Approaches for Elucidating Structures and Interactions of Protein–Ligand Complexes
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    Chapter 8 Neurological Analyses: Focus on Gangliosides and Mass Spectrometry
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    Chapter 9 Mass Spectrometric Analysis of Post-translational Modifications (PTMs) and Protein-Protein Interactions (PPIs).
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    Chapter 10 Applications for Mass Spectrometry in the Study of Ion Channel Structure and Function
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    Chapter 11 A Mass Spectrometry View of Stable and Transient Protein Interactions
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    Chapter 12 Mass Spectrometry-Based Tissue Imaging of Small Molecules
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    Chapter 13 Redox proteomics: from bench to bedside.
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    Chapter 14 Analysis of Fluorinated Proteins by Mass Spectrometry
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    Chapter 15 Mass spectrometry for proteomics-based investigation using the zebrafish vertebrate model system.
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    Chapter 16 Mass Spectrometry-Based Biomarkers in Drug Development
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    Chapter 17 Detection of Biomedically Relevant Stilbenes from Wines by Mass Spectrometry
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    Chapter 18 Mass Spectrometric DNA Adduct Quantification by Multiple Reaction Monitoring and Its Future Use for the Molecular Epidemiology of Cancer
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    Chapter 19 Using Breast Milk to Assess Breast Cancer Risk: The Role of Mass Spectrometry-Based Proteomics
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    Chapter 20 Cancer secretomes and their place in supplementing other hallmarks of cancer.
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    Chapter 21 Thiostrepton, a natural compound that triggers heat shock response and apoptosis in human cancer cells: a proteomics investigation.
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    Chapter 22 Using Proteomics to Unravel the Mysterious Steps of the HBV-Life-Cycle.
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    Chapter 23 Oxidative Stress and Antibiotic Resistance in Bacterial Pathogens: State of the Art, Methodologies, and Future Trends
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    Chapter 24 Proteomic approaches to dissect neuronal signaling pathways.
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    Chapter 25 Investigating a Novel Protein Using Mass Spectrometry: The Example of Tumor Differentiation Factor (TDF).
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    Chapter 26 Mass spectrometry for the study of autism and neurodevelopmental disorders.
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    Chapter 27 Biomarkers in major depressive disorder: the role of mass spectrometry.
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    Chapter 28 Application of Mass Spectrometry to Characterize Localization and Efficacy of Nanoceria In Vivo
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    Chapter 29 Bottlenecks in proteomics.
Attention for Chapter 6: Utility of computational structural biology in mass spectrometry.
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Chapter title
Utility of computational structural biology in mass spectrometry.
Chapter number 6
Book title
Advancements of Mass Spectrometry in Biomedical Research
Published in
Advances in experimental medicine and biology, June 2014
DOI 10.1007/978-3-319-06068-2_6
Pubmed ID
24952181
Book ISBNs
978-3-31-906067-5, 978-3-31-906068-2
Authors

Roy U, Woods AG, Sokolowska I, Darie CC, Urmi Roy, Alisa G. Woods, Izabela Sokolowska, Costel C. Darie

Abstract

Recent developments of mass spectrometry (MS) allow us to identify, estimate, and characterize proteins and protein complexes. At the same time, structural biology helps to determine the protein structure and its structure-function relationship. Together, they aid to understand the protein structure, property, function, protein-complex assembly, protein-protein interaction and dynamics. The present chapter is organized with illustrative results to demonstrate how experimental mass spectrometry can be combined with computational structural biology for detailed studies of protein's structures. We have used tumor differentiation factor protein/peptide as ligand and Hsp70/Hsp90 as receptor protein as examples to study ligand-protein interaction. To investigate possible protein conformation we will describe two proteins, lysozyme and myoglobin.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 3 38%
Student > Ph. D. Student 1 13%
Researcher 1 13%
Student > Master 1 13%
Unknown 2 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 38%
Medicine and Dentistry 3 38%
Agricultural and Biological Sciences 1 13%
Unknown 1 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2014.
All research outputs
#20,238,443
of 22,765,347 outputs
Outputs from Advances in experimental medicine and biology
#3,954
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Outputs of similar age
#192,693
of 228,095 outputs
Outputs of similar age from Advances in experimental medicine and biology
#39
of 42 outputs
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So far Altmetric has tracked 4,928 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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