Chapter title |
Pathological Effects of Exosomes in Mediating Diabetic Cardiomyopathy
|
---|---|
Chapter number | 8 |
Book title |
Exosomes in Cardiovascular Diseases
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-981-10-4397-0_8 |
Pubmed ID | |
Book ISBNs |
978-9-81-104396-3, 978-9-81-104397-0
|
Authors |
Esam S. B. Salem, Guo-Chang Fan, Esam S.B. Salem, Salem, Esam S. B., Fan, Guo-Chang |
Abstract |
Diabetic subjects are at risk of developing cardiovascular disease, which accounts for 60-80% of diabetes-related mortality. Atherosclerosis is still considered as a leading cause of heart failure in diabetic patients, but it could also be an intrinsic and long-term effect of contractile cardiac cells malfunction, known as diabetic cardiomyopathy (DCM). Pathologically, this cardiac dysfunction is manifested by inflammation, apoptosis, fibrosis, hypertrophy and altered cardiomyocytes metabolism. However, the underlying molecular mechanisms of DCM pathophysiology are not clearly understood. Recent and several studies have suggested that exosomes are contributed to the regulation of cell-to-cell communication. Therefore, their in-depth investigation can interpret the complex pathophysiology of DCM. Structurally, exosomes are membrane-bounded vesicles (10-200 nm in diameter), which are actively released from all types of cells and detected in all biological fluids. They carry a wide array of bioactive molecules, including mRNAs, none-coding RNAs (e.g., microRNAs, lncRNAs, circRNAs, etc), proteins and lipids. Importantly, the abundance and nature of loaded molecules inside exosomes fluctuate with cell types and pathological conditions. This chapter summarizes currently available studies on the exosomes' role in the regulation of diabetic cardiomyopathy. Specifically, the advances on the pathological effects of exosomes in diabetic cardiomyopathy as well as the therapeutic potentials and perspectives are also discussed. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 52 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 23% |
Researcher | 6 | 12% |
Student > Master | 5 | 10% |
Student > Doctoral Student | 4 | 8% |
Student > Bachelor | 4 | 8% |
Other | 6 | 12% |
Unknown | 15 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 16 | 31% |
Medicine and Dentistry | 7 | 13% |
Engineering | 3 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Unspecified | 2 | 4% |
Other | 4 | 8% |
Unknown | 18 | 35% |