Chapter title |
Activation of the Innate Immune Receptors: Guardians of the Micro Galaxy
|
---|---|
Chapter number | 1 |
Book title |
Regulation of Inflammatory Signaling in Health and Disease
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-981-10-5987-2_1 |
Pubmed ID | |
Book ISBNs |
978-9-81-105986-5, 978-9-81-105987-2
|
Authors |
Dominic De Nardo, Nardo, Dominic |
Abstract |
The families of innate immune receptors are the frontline responders to danger. These superheroes of the host immune systems populate innate immune cells, surveying the extracellular environment and the intracellular endolysosomal compartments and cytosol for exogenous and endogenous danger signals. As a collective the innate immune receptors recognise a wide array of stimuli, and in response they initiate specific signalling pathways leading to activation of transcriptional or proteolytic pathways and the production of inflammatory molecules to destroy foreign pathogens and/or resolve tissue injury. In this review, I will give an overview of the innate immune system and the activation and effector functions of the families of receptors it comprises. Current key concepts will be described throughout, including innate immune memory, formation of innate immune receptor signalosomes, inflammasome formation and pyroptosis, methods of extrinsic cell communication and examples of receptor cooperation. Finally, several open questions and future directions in the field of innate immunity will be presented and discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 3 | 23% |
Student > Bachelor | 2 | 15% |
Student > Ph. D. Student | 2 | 15% |
Researcher | 2 | 15% |
Professor | 1 | 8% |
Other | 1 | 8% |
Unknown | 2 | 15% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 4 | 31% |
Medicine and Dentistry | 2 | 15% |
Nursing and Health Professions | 1 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
Psychology | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 23% |