Chapter title |
cGAS-STING Activation in the Tumor Microenvironment and Its Role in Cancer Immunity
|
---|---|
Chapter number | 8 |
Book title |
Regulation of Inflammatory Signaling in Health and Disease
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-981-10-5987-2_8 |
Pubmed ID | |
Book ISBNs |
978-9-81-105986-5, 978-9-81-105987-2
|
Authors |
Geneviève Pépin, Michael P. Gantier |
Abstract |
Stimulator of interferon (IFN) genes (STING) is a key mediator in the immune response to cytoplasmic DNA sensed by cyclic GMP-AMP (cGAMP) synthase (cGAS). After synthesis by cGAS, cGAMP acts as a second messenger activating STING in the cell harboring cytoplasmic DNA but also in adjacent cells through gap junction transfer. While the role of the cGAS-STING pathway in pathogen detection is now well established, its importance in cancer immunity has only recently started to emerge. Nonetheless, STING appears to be an essential component in the recruitment of immune cells to the tumor microenvironment, which is paramount to immune clearance of the tumor. This review presents an overview of the growing literature around the role of the cGAS-STING pathway in the tumor microenvironment, with a specific focus on the role that cancer cells may play in the direct activation of this pathway, and its amplification through cell-cell transfer of cGAMP. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 8 | 22% |
Researcher | 8 | 22% |
Student > Ph. D. Student | 6 | 17% |
Student > Master | 4 | 11% |
Lecturer | 2 | 6% |
Other | 3 | 8% |
Unknown | 5 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 11 | 31% |
Medicine and Dentistry | 7 | 19% |
Agricultural and Biological Sciences | 5 | 14% |
Immunology and Microbiology | 4 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Other | 2 | 6% |
Unknown | 5 | 14% |