Copple IM, Goldring CE, Kitteringham NR, Park BK, Copple, Ian M., Goldring, Christopher E., Kitteringham, Neil R., Park, B. Kevin, Ian M. Copple, Christopher E. Goldring, Neil R. Kitteringham, B. Kevin Park
Abstract
Adverse drug reactions pose a significant public health problem. In some cases, the process of drug metabolism can contribute to the onset of toxicity through the bioactivation of a parent molecule to a chemically reactive intermediate. In order to maintain a favorable balance between bioactivation and detoxification, mammalian cells have evolved an inducible cell defense system known as the antioxidant response pathway. The activity of this cytoprotective pathway is largely regulated by the transcription factor Nrf2, which governs the expression of many phase II detoxification and antioxidant enzymes. In turn, the activity of Nrf2 is regulated by the cysteine-rich cytosolic inhibitor Keap1, which acts as a "sensor" for chemical/oxidative stress. This article summarizes our current understanding of the molecular mechanisms that regulate the function of the Keap1-Nrf2 pathway and highlights the importance of Nrf2 in the protection against drug-induced toxicity.
Pharmacology, Toxicology and Pharmaceutical Science
2
4%
Neuroscience
2
4%
Other
9
18%
Unknown
8
16%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2014.
All research outputs
#18,378,085
of 22,763,032 outputs
Outputs from Handbook of experimental pharmacology
#498
of 645 outputs
Outputs of similar age
#84,702
of 92,817 outputs
Outputs of similar age from Handbook of experimental pharmacology
#13
of 14 outputs
Altmetric has tracked 22,763,032 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 645 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 92,817 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.
