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Adverse Drug Reactions

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Cover of 'Adverse Drug Reactions'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Drug-Induced Liver Injury
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    Chapter 2 Drug Hypersensitivity Reactions Involving Skin
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    Chapter 3 Adverse Drug Reactions Affecting Blood Cells
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    Chapter 4 Molecular Mechanisms of Adverse Drug Reactions in Cardiac Tissue
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    Chapter 5 Mechanisms of Drug-Induced Nephrotoxicity
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    Chapter 6 Receptor- and reactive intermediate-mediated mechanisms of teratogenesis.
  8. Altmetric Badge
    Chapter 7 Adverse Drug Reactions
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    Chapter 8 The Role of Cytokines in the Mechanism of Adverse Drug Reactions
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    Chapter 9 The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.
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    Chapter 10 Signal Transduction Pathways Involved in Drug-Induced Liver Injury
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    Chapter 11 Mitochondrial Involvement in Drug-Induced Liver Injury
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    Chapter 12 Mechanisms of Acetaminophen-Induced Liver Necrosis
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    Chapter 13 Drug-Induced Liver Injury in Humans: The Case of Ximelagatran
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    Chapter 14 Troglitazone
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    Chapter 15 Nevirapine Hypersensitivity
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    Chapter 16 Mechanisms of Adverse Drug Reactions to Biologics
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    Chapter 17 Pharmacogenetics of idiosyncratic adverse drug reactions.
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    Chapter 18 The Danger Hypothesis Applied to Idiosyncratic Drug Reactions
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    Chapter 19 Approaches for Minimizing Metabolic Activation of New Drug Candidates in Drug Discovery
Attention for Chapter 9: The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.
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Chapter title
The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.
Chapter number 9
Book title
Adverse Drug Reactions
Published in
Handbook of experimental pharmacology, September 2009
DOI 10.1007/978-3-642-00663-0_9
Pubmed ID
Book ISBNs
978-3-64-200662-3, 978-3-64-200663-0
Authors

Copple IM, Goldring CE, Kitteringham NR, Park BK, Copple, Ian M., Goldring, Christopher E., Kitteringham, Neil R., Park, B. Kevin, Ian M. Copple, Christopher E. Goldring, Neil R. Kitteringham, B. Kevin Park

Abstract

Adverse drug reactions pose a significant public health problem. In some cases, the process of drug metabolism can contribute to the onset of toxicity through the bioactivation of a parent molecule to a chemically reactive intermediate. In order to maintain a favorable balance between bioactivation and detoxification, mammalian cells have evolved an inducible cell defense system known as the antioxidant response pathway. The activity of this cytoprotective pathway is largely regulated by the transcription factor Nrf2, which governs the expression of many phase II detoxification and antioxidant enzymes. In turn, the activity of Nrf2 is regulated by the cysteine-rich cytosolic inhibitor Keap1, which acts as a "sensor" for chemical/oxidative stress. This article summarizes our current understanding of the molecular mechanisms that regulate the function of the Keap1-Nrf2 pathway and highlights the importance of Nrf2 in the protection against drug-induced toxicity.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Spain 1 2%
United States 1 2%
Denmark 1 2%
Unknown 46 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 26%
Student > Ph. D. Student 12 24%
Student > Bachelor 6 12%
Student > Master 6 12%
Other 3 6%
Other 6 12%
Unknown 4 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 34%
Medicine and Dentistry 8 16%
Biochemistry, Genetics and Molecular Biology 4 8%
Neuroscience 2 4%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 10 20%
Unknown 7 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2014.
All research outputs
#18,378,085
of 22,763,032 outputs
Outputs from Handbook of experimental pharmacology
#498
of 645 outputs
Outputs of similar age
#84,702
of 92,817 outputs
Outputs of similar age from Handbook of experimental pharmacology
#13
of 14 outputs
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So far Altmetric has tracked 645 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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