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Adverse Drug Reactions

Overview of attention for book
Cover of 'Adverse Drug Reactions'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Drug-Induced Liver Injury
  3. Altmetric Badge
    Chapter 2 Drug Hypersensitivity Reactions Involving Skin
  4. Altmetric Badge
    Chapter 3 Adverse Drug Reactions Affecting Blood Cells
  5. Altmetric Badge
    Chapter 4 Molecular Mechanisms of Adverse Drug Reactions in Cardiac Tissue
  6. Altmetric Badge
    Chapter 5 Mechanisms of Drug-Induced Nephrotoxicity
  7. Altmetric Badge
    Chapter 6 Receptor- and reactive intermediate-mediated mechanisms of teratogenesis.
  8. Altmetric Badge
    Chapter 7 Adverse Drug Reactions
  9. Altmetric Badge
    Chapter 8 The Role of Cytokines in the Mechanism of Adverse Drug Reactions
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    Chapter 9 The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.
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    Chapter 10 Signal Transduction Pathways Involved in Drug-Induced Liver Injury
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    Chapter 11 Mitochondrial Involvement in Drug-Induced Liver Injury
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    Chapter 12 Mechanisms of Acetaminophen-Induced Liver Necrosis
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    Chapter 13 Drug-Induced Liver Injury in Humans: The Case of Ximelagatran
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    Chapter 14 Troglitazone
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    Chapter 15 Nevirapine Hypersensitivity
  17. Altmetric Badge
    Chapter 16 Mechanisms of Adverse Drug Reactions to Biologics
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    Chapter 17 Pharmacogenetics of idiosyncratic adverse drug reactions.
  19. Altmetric Badge
    Chapter 18 The Danger Hypothesis Applied to Idiosyncratic Drug Reactions
  20. Altmetric Badge
    Chapter 19 Approaches for Minimizing Metabolic Activation of New Drug Candidates in Drug Discovery
Attention for Chapter 12: Mechanisms of Acetaminophen-Induced Liver Necrosis
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#31 of 688)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

1 news outlet
31 X users
35 Facebook pages
6 Wikipedia pages


20 Dimensions

Readers on

425 Mendeley
3 CiteULike
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Chapter title
Mechanisms of Acetaminophen-Induced Liver Necrosis
Chapter number 12
Book title
Adverse Drug Reactions
Published in
Handbook of experimental pharmacology, December 2009
DOI 10.1007/978-3-642-00663-0_12
Pubmed ID
Book ISBNs
978-3-64-200662-3, 978-3-64-200663-0

Hinson JA, Roberts DW, James LP, Jack A. Hinson, Dean W. Roberts, Laura P. James, Hinson, Jack A., Roberts, Dean W., James, Laura P.


Although considered safe at therapeutic doses, at higher doses, acetaminophen produces a centrilobular hepatic necrosis that can be fatal. Acetaminophen poisoning accounts for approximately one-half of all cases of acute liver failure in the United States and Great Britain today. The mechanism occurs by a complex sequence of events. These events include: (1) CYP metabolism to a reactive metabolite which depletes glutathione and covalently binds to proteins; (2) loss of glutathione with an increased formation of reactive oxygen and nitrogen species in hepatocytes undergoing necrotic changes; (3) increased oxidative stress, associated with alterations in calcium homeostasis and initiation of signal transduction responses, causing mitochondrial permeability transition; (4) mitochondrial permeability transition occurring with additional oxidative stress, loss of mitochondrial membrane potential, and loss of the ability of the mitochondria to synthesize ATP; and (5) loss of ATP which leads to necrosis. Associated with these essential events there appear to be a number of inflammatory mediators such as certain cytokines and chemokines that can modify the toxicity. Some have been shown to alter oxidative stress, but the relationship of these modulators to other critical mechanistic events has not been well delineated. In addition, existing data support the involvement of cytokines, chemokines, and growth factors in the initiation of regenerative processes leading to the reestablishment of hepatic structure and function.

X Demographics

X Demographics

The data shown below were collected from the profiles of 31 X users who shared this research output. Click here to find out more about how the information was compiled.
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 425 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 <1%
United Kingdom 2 <1%
Portugal 1 <1%
Netherlands 1 <1%
Chile 1 <1%
Brazil 1 <1%
Germany 1 <1%
Switzerland 1 <1%
Finland 1 <1%
Other 2 <1%
Unknown 410 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 68 16%
Student > Bachelor 63 15%
Student > Master 57 13%
Researcher 38 9%
Student > Doctoral Student 21 5%
Other 64 15%
Unknown 114 27%
Readers by discipline Count As %
Medicine and Dentistry 72 17%
Agricultural and Biological Sciences 65 15%
Pharmacology, Toxicology and Pharmaceutical Science 57 13%
Biochemistry, Genetics and Molecular Biology 49 12%
Chemistry 14 3%
Other 39 9%
Unknown 129 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 44. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2023.
All research outputs
of 26,181,776 outputs
Outputs from Handbook of experimental pharmacology
of 688 outputs
Outputs of similar age
of 176,898 outputs
Outputs of similar age from Handbook of experimental pharmacology
of 14 outputs
Altmetric has tracked 26,181,776 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 688 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,898 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.