Chapter title |
Orexin/Hypocretin Signaling
|
---|---|
Chapter number | 49 |
Book title |
Behavioral Neuroscience of Orexin/Hypocretin
|
Published in |
Current topics in behavioral neurosciences, January 2016
|
DOI | 10.1007/7854_2016_49 |
Pubmed ID | |
Book ISBNs |
978-3-31-957534-6, 978-3-31-957535-3
|
Authors |
Jyrki P. Kukkonen, Kukkonen, Jyrki P. |
Abstract |
Orexin/hypocretin peptide (orexin-A and orexin-B) signaling is believed to take place via the two G-protein-coupled receptors (GPCRs), named OX1 and OX2 orexin receptors, as described in the previous chapters. Signaling of orexin peptides has been investigated in diverse endogenously orexin receptor-expressing cells - mainly neurons but also other types of cells - and in recombinant cells expressing the receptors in a heterologous manner. Findings in the different systems are partially convergent but also indicate cellular background-specific signaling. The general picture suggests an inherently high degree of diversity in orexin receptor signaling.In the current chapter, I present orexin signaling on the cellular and molecular levels. Discussion of the connection to (potential) physiological orexin responses is only brief since these are in focus of other chapters in this book. The same goes for the post-synaptic signaling mechanisms, which are dealt with in Chapter 5. The current chapter is organized according to the tissue type, starting from the central nervous system. Finally, receptor signaling pathways are discussed across tissues, cell types, and even species. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 27% |
Student > Doctoral Student | 4 | 15% |
Other | 2 | 8% |
Student > Bachelor | 1 | 4% |
Student > Master | 1 | 4% |
Other | 2 | 8% |
Unknown | 9 | 35% |
Readers by discipline | Count | As % |
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Neuroscience | 7 | 27% |
Medicine and Dentistry | 4 | 15% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Nursing and Health Professions | 1 | 4% |
Mathematics | 1 | 4% |
Other | 1 | 4% |
Unknown | 10 | 38% |