| Chapter title |
Orexin and Alzheimer’s Disease
|
|---|---|
| Chapter number | 50 |
| Book title |
Behavioral Neuroscience of Orexin/Hypocretin
|
| Published in |
Current topics in behavioral neurosciences, December 2016
|
| DOI | 10.1007/7854_2016_50 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-957534-6, 978-3-31-957535-3
|
| Authors |
Liguori, Claudio, Claudio Liguori |
| Abstract |
Alzheimer's disease (AD) is the most frequent age-related dementia. It prevalently causes cognitive decline, although it is frequently associated with secondary behavioral disturbances. AD neurodegeneration characteristically produces a remarkable destruction of the sleep-wake cycle, with diurnal napping, nighttime arousals, sleep fragmentation, and REM sleep impairment. It was recently hypothesized that the orexinergic system was involved in AD pathology. Accordingly, recent papers showed the association between orexinergic neurotransmission dysfunction, sleep impairment, and cognitive decline in AD. Orexin is a hypothalamic neurotransmitter which physiologically produces wakefulness and reduces REM sleep and may alter the sleep-wake cycle in AD patients. Furthermore, the orexinergic system seems to interact with CSF AD biomarkers, such as beta-amyloid and tau proteins. Beta-amyloid accumulation is the main hallmark of AD pathology, while tau proteins mark brain neuronal injury due to AD pathology. Investigations so far suggest that orexinergic signaling overexpression alters the sleep-wake cycle and secondarily induces beta-amyloid accumulation and tau-mediated neurodegeneration. Therefore, considering that orexinergic system dysregulation impairs sleep-wake rhythms and may influence AD pathology, it is hypothesized that orexin receptor antagonists are likely potential preventive/therapeutic options in AD patients. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 99 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 14% |
| Student > Bachelor | 13 | 13% |
| Student > Master | 8 | 8% |
| Student > Doctoral Student | 6 | 6% |
| Researcher | 6 | 6% |
| Other | 22 | 22% |
| Unknown | 32 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 17% |
| Neuroscience | 13 | 13% |
| Biochemistry, Genetics and Molecular Biology | 12 | 12% |
| Psychology | 8 | 8% |
| Agricultural and Biological Sciences | 3 | 3% |
| Other | 12 | 12% |
| Unknown | 36 | 36% |