Chapter title |
The Hypocretin/Orexin Neuronal Networks in Zebrafish
|
---|---|
Chapter number | 59 |
Book title |
Behavioral Neuroscience of Orexin/Hypocretin
|
Published in |
Current topics in behavioral neurosciences, January 2016
|
DOI | 10.1007/7854_2016_59 |
Pubmed ID | |
Book ISBNs |
978-3-31-957534-6, 978-3-31-957535-3
|
Authors |
Idan Elbaz, Talia Levitas-Djerbi, Lior Appelbaum |
Abstract |
The hypothalamic Hypocretin/Orexin (Hcrt) neurons secrete two Hcrt neuropeptides. These neurons and peptides play a major role in the regulation of feeding, sleep wake cycle, reward-seeking, addiction, and stress. Loss of Hcrt neurons causes the sleep disorder narcolepsy. The zebrafish has become an attractive model to study the Hcrt neuronal network because it is a transparent vertebrate that enables simple genetic manipulation, imaging of the structure and function of neuronal circuits in live animals, and high-throughput monitoring of behavioral performance during both day and night. The zebrafish Hcrt network comprises ~16-60 neurons, which similar to mammals, are located in the hypothalamus and widely innervate the brain and spinal cord, and regulate various fundamental behaviors such as feeding, sleep, and wakefulness. Here we review how the zebrafish contributes to the study of the Hcrt neuronal system molecularly, anatomically, physiologically, and pathologically. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Chile | 1 | 2% |
Unknown | 44 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 16% |
Researcher | 4 | 9% |
Professor | 4 | 9% |
Student > Bachelor | 4 | 9% |
Student > Doctoral Student | 3 | 7% |
Other | 11 | 24% |
Unknown | 12 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 10 | 22% |
Agricultural and Biological Sciences | 7 | 16% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Medicine and Dentistry | 4 | 9% |
Social Sciences | 2 | 4% |
Other | 4 | 9% |
Unknown | 14 | 31% |