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Proteomics for Drug Discovery

Overview of attention for book
Cover of 'Proteomics for Drug Discovery'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 A Photoaffinity Labeling-Based Chemoproteomics Strategy for Unbiased Target Deconvolution of Small Molecule Drug Candidates
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    Chapter 2 Multiplexed Liquid Chromatography-Multiple Reaction Monitoring Mass Spectrometry Quantification of Cancer Signaling Proteins
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    Chapter 3 Monitoring Dynamic Changes of the Cell Surface Glycoproteome by Quantitative Proteomics
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    Chapter 4 High-Resolution Parallel Reaction Monitoring with Electron Transfer Dissociation for Middle-Down Proteomics: An Application to Study the Quantitative Changes Induced by Histone Modifying Enzyme Inhibitors and Activators
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    Chapter 5 Preparation and Immunoaffinity Depletion of Fresh Frozen Tissue Homogenates for Mass Spectrometry-Based Proteomics in the Context of Drug Target/Biomarker Discovery
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    Chapter 6 Target Identification Using Cell Permeable and Cleavable Chloroalkane Derivatized Small Molecules
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    Chapter 7 Microfluidics-Mass Spectrometry of Protein-Carbohydrate Interactions: Applications to the Development of Therapeutics and Biomarker Discovery
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    Chapter 8 Studying Protein–Protein Interactions by Biotin AP-Tagged Pulldown and LTQ-Orbitrap Mass Spectrometry
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    Chapter 9 Post-Translational Modification Profiling-Functional Proteomics for the Analysis of Immune Regulation
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    Chapter 10 Reverse Phase Protein Arrays and Drug Discovery
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    Chapter 11 Probing Protein Kinase-ATP Interactions Using a Fluorescent ATP Analog
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    Chapter 12 Preparation of Disease-Related Protein Assemblies for Single Particle Electron Microscopy
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    Chapter 13 Identification of Lipid Binding Modulators Using the Protein-Lipid Overlay Assay
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    Chapter 14 Resazurin Live Cell Assay: Setup and Fine-Tuning for Reliable Cytotoxicity Results
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    Chapter 15 Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows
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    Chapter 16 Method to Identify Silent Codon Mutations That May Alter Peptide Elongation Kinetics and Co-translational Protein Folding
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    Chapter 17 In Silico Design of Anticancer Peptides
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    Chapter 18 Docking and Virtual Screening in Drug Discovery
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    Chapter 19 Bioinformatics Resources for Interpreting Proteomics Mass Spectrometry Data
  21. Altmetric Badge
    Chapter 20 Erratum to: Probing Protein Kinase-ATP Interactions Using a Fluorescent ATP Analog
Attention for Chapter 3: Monitoring Dynamic Changes of the Cell Surface Glycoproteome by Quantitative Proteomics
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Chapter title
Monitoring Dynamic Changes of the Cell Surface Glycoproteome by Quantitative Proteomics
Chapter number 3
Book title
Proteomics for Drug Discovery
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-7201-2_3
Pubmed ID
Book ISBNs
978-1-4939-7200-5, 978-1-4939-7201-2
Authors

Mathias Kalxdorf, Hans Christian Eberl, Marcus Bantscheff

Abstract

The analysis of the cell surface accessible proteome provides invaluable information about cellular identity, cellular functions, and interactions. Cell surface labeling in combination with quantitative proteomics enables the unbiased identification and quantification of cell surface proteins. We describe a fast, efficient, and robust protocol for the enrichment of the N-linked plasma membrane glycoproteome and subsequent analysis by mass spectrometry. Precise and multiplexed quantification of relative changes of cell surface protein presentation is enabled by an isobaric labeling strategy.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 33%
Other 2 17%
Professor 1 8%
Student > Bachelor 1 8%
Professor > Associate Professor 1 8%
Other 1 8%
Unknown 2 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 25%
Agricultural and Biological Sciences 2 17%
Computer Science 2 17%
Chemistry 2 17%
Medicine and Dentistry 1 8%
Other 0 0%
Unknown 2 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2017.
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#20,442,790
of 22,997,544 outputs
Outputs from Methods in molecular biology
#9,933
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Outputs of similar age
#356,128
of 421,208 outputs
Outputs of similar age from Methods in molecular biology
#842
of 1,074 outputs
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