| Chapter title |
The Regulation and Function of Cohesin and Condensin in Mammalian Oocytes and Spermatocytes
|
|---|---|
| Chapter number | 15 |
| Book title |
Oocytes
|
| Published in |
Results and problems in cell differentiation, January 2017
|
| DOI | 10.1007/978-3-319-60855-6_15 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-960854-9, 978-3-31-960855-6
|
| Authors |
Jibak Lee |
| Abstract |
Germ cells, such as oocytes and spermatocytes, produce haploid gametes by a special type of cell division called meiosis. The reduction of chromosome number is achieved in meiosis I, in which homologous chromosomes (homologs) are paired and recombined with their counterparts and finally segregated from each other. How meiotic chromosomes behave in a different manner from mitotic chromosomes has been a fascinating problem for cellular and developmental biology. Cohesin and condensin are multi-subunit protein complexes that play central roles in sister chromatid cohesion and chromosome condensation (also segregation), respectively. Recent studies investigating the expression and function of cohesin and condensin in mammalian germ cells greatly advance our understanding of the molecular mechanism underlying the meiotic chromosomal events. Furthermore, accumulating evidence suggests that reduction of cohesin during prophase I arrest in mammalian oocytes is one of the major causes for age-related chromosome segregation error. This review focuses on the regulation and functions of cohesins and condensins during mammalian meiosis. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 23% |
| Student > Bachelor | 2 | 15% |
| Professor | 2 | 15% |
| Student > Master | 1 | 8% |
| Researcher | 1 | 8% |
| Other | 2 | 15% |
| Unknown | 2 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
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| Agricultural and Biological Sciences | 2 | 15% |
| Psychology | 1 | 8% |
| Unknown | 2 | 15% |